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质量水平
方案
≥90% (HPLC)
表单
powder
颜色
dark brown to black
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
−20°C
InChI
1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2
InChI key
LYPFDBRUNKHDGX-UHFFFAOYSA-N
一般描述
替莫卟吩/（四[间羟基苯基]二氢卟酚，m-THPC）是疏水性第二代光敏剂。通过光动力疗法用于晚期头颈癌患者的姑息治疗。
生化/生理作用
替莫卟吩是用于光动力疗法的光敏剂。 替莫卟吩已在临床上用于治疗晚期头颈部鳞状细胞癌，并且正在研究用于其他几种癌症。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
T Hauge et al.
Photodiagnosis and photodynamic therapy, 13, 330-333 (2015-09-30)
Photodynamic therapy (PDT) in combination with stent have shown promising results in the treatment of biliary tract cancer (BTC) in patients not suitable for surgery. Chemotherapy has been shown to improve survival in patients with local advanced and metastatic BTC.
Andrej Wagner et al.
Hepatology (Baltimore, Md.), 62(5), 1456-1465 (2015-05-21)
Photodynamic therapy using porfimer (P-PDT) improves palliation and survival in nonresectable hilar bile duct cancer. Tumoricidal penetration depth of temoporfin-PDT (T-PDT) is twice that of P-PDT. In a single-arm phase II study we investigated the safety, efficacy, survival time, and
Distribution of temoporfin, a new photosensitizer for the photodynamic therapy of cancer, in a murine tumor model
Whelpton R, et al.
Photochemistry and Photobiology, 61(4), 397-401 (1995)
Amandine Pinto et al.
ACS nano, 15(2), 3251-3263 (2021-01-23)
The dissemination of tumor metastasis in the peritoneal cavity, also called peritoneal metastasis (PM) or carcinomatosis, represents a late stage of gastrointestinal and gynecological cancer with very poor prognosis, even when cytoreductive surgery is effective, due to residual microscopic disease.
Temoporfin-loaded liposomes: physicochemical characterization
Kuntsche J, et al.
European Journal of Pharmaceutical Sciences, 40(4), 305-315 (2010)
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