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Merck
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安全信息

SML1701

Sigma-Aldrich

BX430

≥98% (HPLC)

别名:

N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N′-(3-pyridinyl)urea

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About This Item

经验公式（希尔记法）:
C15H15Br2N3O
CAS号:
688309-70-8
分子量:
413.11
MDL编号:
MFCD02678819
UNSPSC代码:
12352200
PubChem化学物质编号:
329826026
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES字符串

BrC1=CC(C(C)C)=CC(Br)=C1NC(NC2=CC=CN=C2)=O

InChI

1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)

InChI key

JFNKIJKRXKPQCC-UHFFFAOYSA-N

生化/生理作用

BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels.
BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels. P2X4 receptors are highly expressed in the CNS, and have been studied as a therapeutic target for neuropathic pain and inflammation, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. BX430 is highly selective for human P2X4, with minimal activity towards other P2X subtypes, including P2X1–P2X3, P2X5, and P2X7. BX430 is also an antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 receptors. BX430 has an IC50 value of 540 nM.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
086M4603V

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