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![鸟苷5′-[β,γ-亚氨基]三磷酸 三钠盐 水合物 ≥85% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/204/494/05808804-1ca7-44bf-b6c5-d4934dc7cb85/640/05808804-1ca7-44bf-b6c5-d4934dc7cb85.png)
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear
储存温度
2-8°C
SMILES字符串
ClC1=C(C(NN)=O)SC2=CC=CC(Cl)=C21
InChI
1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)
InChI key
HSSHUDKWJRJKPV-UHFFFAOYSA-N
一般描述
抑制 8-氧代鸟嘌呤 DNA 糖基化酶-1（OGG1），可用于治疗某些类型的癌症的单一疗法或联合疗法。
生化/生理作用
OGG1 抑制剂 O8 是 8-氧鸟嘌呤 DNA 糖基化酶 1（OGG1）的有效抑制剂，该酶是 DNA 碱基切除修复（BER）途径的一部分，正在成为癌症治疗的药物靶标。 OGG1 抑制剂 O8 的 IC50 值为 220 nM，相对于其他几种 DNA 修复糖基化酶，其对 OGG1 的选择性为 >100 倍。 O8 在 OGG1 催化过程中通过抑制席夫碱的形成发挥作用。它不能阻止 OGG1 与包含 7,8-二氢-8-氧鸟嘌呤（8-氧代-瓜氨酸）的底物的 DNA 结合。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Mingxin Chang et al.
Frontiers in pharmacology, 11, 610205-610205 (2021-02-02)
Background: Oncogenic transformation is associated with elevated oxidative stress that promotes tumor progression but also renders cancer cells vulnerable to further oxidative insult. Agents that stimulate ROS generation or suppress antioxidant systems can drive oxidative pressure to toxic levels selectively
Nathan Donley et al.
ACS chemical biology, 10(10), 2334-2343 (2015-07-29)
The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination. Early results from clinical trials suggest
Xu Zheng et al.
Journal of innate immunity, 1-22 (2022-05-06)
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these processes are not fully understood.
Yaoyao Xue et al.
Frontiers in immunology, 14, 1161160-1161160 (2023-08-21)
Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections. Activated transcription factors in conjunction with chromatin remodelers induce epigenetic changes that reprogram IFN responses. Unexpectedly, 8-oxoguanine
Wenjing Hao et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7427-7441 (2020-05-08)
8-Oxoguanine DNA glycosylase1 (OGG1)-initiated base excision repair (BER) is the primary pathway to remove the pre-mutagenic 8-oxo-7,8-dihydroguanine (8-oxoG) from DNA. Recent studies documented 8-oxoG serves as an epigenetic-like mark and OGG1 modulates gene expression in oxidatively stressed cells. For this
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