所有图片(1)
About This Item
经验公式（希尔记法）:
C20H20N2O2
CAS号:
分子量:
320.39
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1
InChI
1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23)
InChI key
GVGVYDCVFBGALZ-UHFFFAOYSA-N
生化/生理作用
CDN1163处理可降低与糖异生和脂肪生成有关的基因的肝表达，同时减弱内质网（ER）应激反应和ER应激诱导的细胞凋亡。CDN1163可与肌膜/内质网Ca2+-ATPase（SERCA）发生相互作用，并增强ER Ca2+的内含量。
CDN1163是肌/内质网Ca2+-ATPase（SERCA）的一种变构激活剂，可有效降低ob/ob小鼠的空腹血糖，改善的葡萄糖耐量和肝脂肪变性。另外，CDN1163可诱导肥胖组织重量显著减少，而对ob/ob小鼠的瘦体重没有影响。CDN1163对瘦对照小鼠的葡萄糖水平或体重没有影响。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Katherine Krajnak et al.
Bioorganic & medicinal chemistry letters, 28(9), 1591-1594 (2018-04-01)
Amongst the cellular cacophony of altered signals in Alzheimer's disease (AD), disrupted Ca2+ homeostasis and consequential endoplasmic reticulum (ER) stress signals have been recognized as key determinants of neuron fate. This altered Ca2+ state is accompanied by a failing sarco/endoplasmic
Russell Dahl
Bioorganic & medicinal chemistry, 25(1), 53-57 (2016-10-26)
Endoplasmic reticulum (ER) stress is intimately linked to Parkinson's disease (PD) pathophysiology. Disrupted intracellular calcium homeostasis is a major cause of the ER stress seen in dopaminergic neurons, leading to the cell death and subsequent loss of movement and coordination
Cytoprotective small molecule modulators of endoplasmic reticulum stress.
Munshi S and Russell D
Bioorganic & Medicinal Chemistry, 24(11), 2382-2388 (2016)
Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders.
Kang S, et al.
The Journal of Biological Chemistry, 391(10), 5185-5198 (2016)
M'Lynn E Fisher et al.
eLife, 10 (2021-06-03)
The sarco-plasmic reticulum calcium pump (SERCA) plays a critical role in the contraction-relaxation cycle of muscle. In cardiac muscle, SERCA is regulated by the inhibitor phospholamban. A new regulator, dwarf open reading frame (DWORF), has been reported to displace phospholamban
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