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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CN(C1)CCC2=C1C=CC(NC3=NC=C(C4CC4)C(NCCCNC(C5CCC5)=O)=N3)=C2.[H]Cl.[H]Cl
InChI
1S/C25H34N6O.2ClH/c1-31-13-10-19-14-21(9-8-20(19)16-31)29-25-28-15-22(17-6-7-17)23(30-25)26-11-3-12-27-24(32)18-4-2-5-18;;/h8-9,14-15,17-18H,2-7,10-13,16H2,1H3,(H,27,32)(H2,26,28,29,30);2*1H
InChI key
NLKPLTWKINJHCK-UHFFFAOYSA-N
应用
MRT68921二盐酸盐的应用：
- 作为SH-SY5Y神经母细胞瘤细胞中Unc-51样激酶1(ULK1)的抑制剂
- 作为肝内淋巴细胞中ULK1和ULK2激酶的抑制剂
- 检测其作为ULK1抑制剂，对泛素特异性肽酶24(USP24)敲低人神经胶质瘤H4细胞中自噬体积聚的缓解作用
生化/生理作用
MRT68921 是体外 ULK1 和 ULK2 激酶的细胞渗透的、高效和特异性抑制剂，可降低细胞中 ULK1 的活性并阻止自噬诱导。MRT68921 阻断 mTOR 依赖性自噬。
MRT68921具有细胞毒性，通过作用于氧化应激信号而杀死癌细胞，是一种有效的肿瘤治疗药物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Yiran Chen et al.
Cell death & disease, 11(8), 712-712 (2020-09-03)
Utilizing oxidative stress has recently been regarded as a potential strategy for tumor therapy. The NUAK family SNF1-like kinase 1 (NUAK1) is a critical component of the antioxidant defense system and is necessary for the survival of tumors. Therefore, NUAK1
Leo Swadling et al.
Cell reports, 30(3), 687-698 (2020-01-23)
Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionality in the immunosuppressive liver environment. By
Julia A Thayer et al.
Autophagy, 16(1), 140-153 (2019-04-09)
Recent studies indicate a causative relationship between defects in autophagy and dopaminergic neuron degeneration in Parkinson disease (PD). However, it is not fully understood how autophagy is regulated in the context of PD. Here we identify USP24 (ubiquitin specific peptidase
Yasuomi Urano et al.
Autophagy, 14(11), 1943-1958 (2018-08-17)
PARK7/DJ-1 is a Parkinson disease- and cancer-associated protein that functions as a multifunctional protein involved in gene transcription regulation and anti-oxidative defense. Although PARK7 lacks the secretory signal sequence, it is secreted and plays important physiological and pathophysiological roles. Whereas
Anna M Schläfli et al.
Scientific reports, 11(1), 9011-9011 (2021-04-29)
ALK inhibitors effectively target EML4-ALK positive non-small cell lung cancer, but their effects are hampered by treatment resistance. In the present study, we asked whether ALK inhibition affects autophagy, and whether this may influence treatment response. Whereas the impact of
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