所有图片(1)
About This Item
经验公式（希尔记法）:
C24H21F2NO3
CAS号:
分子量:
409.43
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
powder
溶解性
DMF: soluble ≥15 mg/mL
DMSO: soluble ≥15 mg/mL
ethanol: soluble ≥15 mg/mL
methanol: soluble ≥15 mg/mL
储存温度
2-8°C
SMILES字符串
FC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O
InChI
1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
InChI key
OLNTVTPDXPETLC-XPWALMASSA-N
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生化/生理作用
依泽替米贝是一种非他汀类药物，可减少肠道胆固醇的吸收。此外，它还能够降低患有急性冠状动脉综合征且低密度脂蛋白（LDL）胆固醇值在指南建议范围内的患者的心血管事件风险。
依泽替米贝通过阻止Niemann-Pick C1样1（NPC1L1）蛋白对胆固醇的吸收来抑制肠道胆固醇的吸收，该蛋白被发现对胆固醇的肠道吸收至关重要。 依泽替米贝选择性地阻断胆固醇的吸收，而不会抑制肠腔中的胰腺脂解酶活性。
重悬
对于在水性缓冲液中的溶解度，应将依泽替米贝溶解在乙醇中，然后用缓冲液稀释。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ezetimibe added to statin therapy after acute coronary syndromes.
Cannon C P, et al.
The New England Journal of Medicine, 372(25), 2387-2397 (2015)
Garcia-Calvo, et al.
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Wojciech G Garbacz et al.
Molecular pharmacology, 94(4), 1145-1154 (2018-07-27)
Cholesterol is essential for numerous biologic functions and processes, but an excess of intracellular cholesterol can be toxic. Intestinal cholesterol absorption is a major determinant of plasma cholesterol level. The liver X receptor (LXR) is a nuclear receptor known for
Jing Yu et al.
Oxidative medicine and cellular longevity, 2020, 4717258-4717258 (2020-01-31)
Oxidative stress and neuroinflammation play essential roles in ischemic stroke-induced brain injury. Previous studies have reported that Ezetimibe (Eze) exerts antioxidative stress and anti-inflammatory properties in hepatocytes. In the present study, we investigated the effects of Eze on oxidative stress
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