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产品名称
OSMI-1, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(N1)C=CC2=C1C=CC(S(N[C@H](C3=C(OC)C=CC=C3)C(N(CC4=CC=CS4)CC5=CC=CO5)=O)(=O)=O)=C2
InChI
1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1
InChI key
IYIGLWQQAMROOF-HHHXNRCGSA-N
应用
OSMI-1(OGT的小分子抑制剂)已可用于邻位连接分析、Sox2(SRY(性别决定区Y)-Box 2)双荧光素酶报告基因检测、Sox2 ELISA(酶联免疫吸附测定)以及其他 体内 方法 ,以研究 O-连接的β-N-乙酰氨基葡萄糖(O-GlcNAc)介导的癌症自我更新基因的调控。它还被用于研究由O-GlcNAc转移酶介导的Hippo途径调节。
生化/生理作用
OSMI-1是一种细胞渗透性OGT(O-GlcNAc转移酶)抑制剂。
在翻译后修饰过程中,OGT可催化 N-乙酰葡糖胺部分与多种蛋白质的连接。抑制OGT活性,可能会降低病毒在感染过程中的复制率,如单纯疱疹病毒性疾病。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种:
分析证书(COA)
O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer.
bioRxiv, 345223-345223 (2018)
O-GlcNAc transferase inhibitors: current tools and future challenges.
Biochemical Society Transactions, 44(1), 88-93 (2016)
Regulation of the hippo-YAP pathway by glucose sensor O-GlcNAcylation.
Molecular Cell, 68(3), 591-604 (2018)
Bioprocess and biosystems engineering, 43(5), 863-875 (2020-01-26)
O-Glycosylation occurs in recombinant proteins produced by CHO cells, but this phenomenon has not been studied extensively. Here, we report that rituximab is an O-linked N-acetyl-glucosaminylated (O-GlcNAcylated) protein and the production of rituximab is increased by thiamet G, an inhibitor
Theranostics, 9(12), 3410-3424 (2019-07-10)
Pancreatic adenocarcinoma (PDAC) claims more than 90% of the patients diagnosed with the disease owing to its aggressive biology that is manifested by high rate of tumor recurrence. Aberrant upregulation in the transcriptional activity of proteins involved in self-renewal like
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