SML1620
NGI-1
≥95% (HPLC), Asparagine (N)-linked glycoslysation inhibitor, powder
别名:
5-[（二甲基氨基）磺酰基] -N-（5-甲基-2-噻唑基）-2-（1-吡咯烷基）-苯甲酰胺, ML414
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关于此项目
产品名称
NGI-1, ≥95% (HPLC)
Quality Level
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C
InChI key
QPKGRLIYJGBKJL-UHFFFAOYSA-N
Biochem/physiol Actions
NGI-1（ML414）是天冬酰胺（N）连锁糖酵解的一种抑制剂。
NGI-1（ML414）是天冬酰胺（N）连锁糖酵解的一种抑制剂。 NGI-1可抑制寡糖基转移酶，防止其附着于蛋白质上。 NGI-1已显示可在受体酪氨酸激酶依赖性肿瘤中诱导衰老。
存储类别
11 - Combustible Solids
wgk
WGK 3
Angelyn Larkin et al.
Biochemistry, 50(21), 4411-4426 (2011-04-22)
Asparagine-linked glycosylation involves the sequential assembly of an oligosaccharide onto a polyisoprenyl donor, followed by the en bloc transfer of the glycan to particular asparagine residues within acceptor proteins. These N-linked glycans play a critical role in a wide variety
Cecilia Lopez-Sambrooks et al.
Nature chemical biology, 12(12), 1023-1030 (2016-10-25)
Asparagine (N)-linked glycosylation is a protein modification critical for glycoprotein folding, stability, and cellular localization. To identify small molecules that inhibit new targets in this biosynthetic pathway, we initiated a cell-based high-throughput screen and lead-compound-optimization campaign that delivered a cell-permeable
Danielle Skropeta
Bioorganic & medicinal chemistry, 17(7), 2645-2653 (2009-03-17)
In a series of investigations, N-glycosylation has proven to be a key determinant of enzyme secretion, activity, binding affinity and substrate specificity, enabling a protein to fine-tune its activity. In the majority of cases elimination of all putative N-glycosylation sites
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1620-5MG | 04061833066959 |
| SML1620-25MG | 04061833066942 |