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质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C
InChI key
QPKGRLIYJGBKJL-UHFFFAOYSA-N
生化/生理作用
NGI-1（ML414）是天冬酰胺（N）连锁糖酵解的一种抑制剂。
NGI-1（ML414）是天冬酰胺（N）连锁糖酵解的一种抑制剂。 NGI-1可抑制寡糖基转移酶，防止其附着于蛋白质上。 NGI-1已显示可在受体酪氨酸激酶依赖性肿瘤中诱导衰老。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Angelyn Larkin et al.
Biochemistry, 50(21), 4411-4426 (2011-04-22)
Asparagine-linked glycosylation involves the sequential assembly of an oligosaccharide onto a polyisoprenyl donor, followed by the en bloc transfer of the glycan to particular asparagine residues within acceptor proteins. These N-linked glycans play a critical role in a wide variety
Danielle Skropeta
Bioorganic & medicinal chemistry, 17(7), 2645-2653 (2009-03-17)
In a series of investigations, N-glycosylation has proven to be a key determinant of enzyme secretion, activity, binding affinity and substrate specificity, enabling a protein to fine-tune its activity. In the majority of cases elimination of all putative N-glycosylation sites
Cecilia Lopez-Sambrooks et al.
Nature chemical biology, 12(12), 1023-1030 (2016-10-25)
Asparagine (N)-linked glycosylation is a protein modification critical for glycoprotein folding, stability, and cellular localization. To identify small molecules that inhibit new targets in this biosynthetic pathway, we initiated a cell-based high-throughput screen and lead-compound-optimization campaign that delivered a cell-permeable
Shih-Han Wang et al.
American journal of cancer research, 12(10), 4721-4736 (2022-11-17)
N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack. Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development. PTM of SLAMF7
Ryan A Flynn et al.
Cell, 184(12), 3109-3124 (2021-05-19)
Glycans modify lipids and proteins to mediate inter- and intramolecular interactions across all domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge this view with evidence that mammals use RNA as a
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