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方案
≥95% (HPLC)
表单
powder
颜色
white to light brown
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
InChI
1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)
InChI key
YBGGBHCJSAEIAS-UHFFFAOYSA-N
一般描述
LIMK1 (LIM domain kinase 1) belongs to the serine-threonine protein kinases. The gene is mapped to human chromosome 7q11.
生化/生理作用
BMS-3 shows cytotoxic effects not related to LIMK, but rather through reduction of the levels of tubulin transcripts and induction of mitotic arrest.
It is a specific inhibitor of LIMK1. LIMK1 is responsible for the inactivation of cofilin (ADF family protein), leading to actin reorganization. It is upregulated in several invasive cancers.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Puxiang Chen et al.
Oncology reports, 32(5), 2070-2076 (2014-09-06)
LIM kinase 1 (Limk1) is associated with cell prolife-ration and metastasis and its dysregulated expression has been observed in many types of cancer. The present study aimed to examine the role of Limk1 in the development of ovarian cancer, as
D W Martindale et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 11(10), 890-898 (2000-09-26)
Williams syndrome (WS) is a complex neurodevelopmental disorder arising from a microdeletion at Chr band 7q11.23, which results in a hemizygous condition for a number of genes. Within this region we have completely characterized 200 kb containing the genes LIMK1
Ana Romarowski et al.
Developmental biology, 405(2), 237-249 (2015-07-15)
Mammalian sperm must acquire their fertilizing ability after a series of biochemical modifications in the female reproductive tract collectively called capacitation to undergo acrosomal exocytosis, a process that is essential for fertilization. Actin dynamics play a central role in controlling
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