所有图片(1)
别名:
(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, Amyloid-β Forty-Two Inducer 4, N6-Methyl-(R)-roscovitine
经验公式（希尔记法）:
C20H28N6O
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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
protect from light
颜色
white to beige
溶解性
DMSO: 25 mg/mL, clear
储存温度
−20°C
生化/生理作用
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.
WGK
WGK 3
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