所有图片(1)
About This Item
经验公式（希尔记法）:
C18H16Cl2N4
CAS号:
分子量:
359.25
MDL编号:
UNSPSC代码:
12171501
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to light brown
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1
InChI
1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)
InChI key
ABGOSOMRWSYAOB-UHFFFAOYSA-N
相关类别
生化/生理作用
A-196是SUV420H1和SUV420H2的一种有效且选择性的化学抑制剂，可抑制多种细胞系中H4K20me的二甲基和三甲基化。有关表征的完整详细信息，请访问结构基因组学联盟（SGC）网站上的 A-196 探针摘要 。
SGC2043是活性探针A-196的阴性对照。若需向SGC索要阴性对照样品，请 点击这里。
想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
SGC2043是活性探针A-196的阴性对照。若需向SGC索要阴性对照样品，请 点击这里。
想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
特点和优势
A-196是一种表观遗传化学探针，通过与Structural Genomics Consortium（SGC）合作获得。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。
该化合物是基因调控研究推荐产品。点击此处 ，查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Xin Cui et al.
JCI insight, 9(11) (2024-05-07)
Activation of brown adipose tissue (BAT) thermogenesis increases energy expenditure and alleviates obesity. Here we discover that histone methyltransferase suppressor of variegation 4-20 homolog 2 (Suv420h2) expression parallels that of Ucp1 in brown and beige adipocytes and that Suv420h2 knockdown
Wendan Ren et al.
Nature communications, 12(1), 2490-2490 (2021-05-05)
DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk. Here, we report that DNA
Alena Svobodová Kovaříková et al.
Cells, 9(2) (2020-02-09)
The DNA damage response is mediated by both DNA repair proteins and epigenetic markers. Here, we observe that N6-methyladenosine (m6A), a mark of the epitranscriptome, was common in RNAs accumulated at UV-damaged chromatin; however, inhibitors of RNA polymerases I and
Dalia Rosano et al.
Cancer discovery, 14(5), 866-889 (2024-03-26)
Patients with estrogen receptor-positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients relapse even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic
Virginia López et al.
Frontiers in cell and developmental biology, 9, 671838-671838 (2021-08-28)
Glioblastoma multiforme (GBM) is the most common and aggressive type of brain tumor in adulthood. Epigenetic mechanisms are known to play a key role in GBM although the involvement of histone methyltransferase KMT5B and its mark H4K20me2 has remained largely
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