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产品名称
尤达1, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
[s]1c(nnc1c3nccnc3)SCc2c(cccc2Cl)Cl
InChI
1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
InChI key
BQNXBSYSQXSXPT-UHFFFAOYSA-N
一般描述
Yoda1 是一种新型合成小分子，被开发用于研究阳离子通道压敏离子通道成分 1 (Piezo1) 的动力学、调控和功能。
应用
Yoda1 已被用于研究其对异源三聚体 Piezo1 通道的影响。
生化/生理作用
Yoda1 是小鼠和人类阳离子通道 Piezo1 的特异性激活剂，Piezo1 是介导机械激活时 Ca 2 + 内流的机械敏感性通道，与血管发育有关。 Yoda1 稳定 Piezo1 开放通道。在红细胞中，随后 KCa3.1 Gardos 通道下游激活，导致钙内流以及钾和水外流，引起细胞收缩。Yoda1 是首个压电 1 激动剂，首次提供了压电通道非机械激活的证据。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Lei Liu et al.
Frontiers in pharmacology, 12, 606245-606245 (2021-04-13)
XueShuanTong (XST) comprising therapeutically active ginsenosides, a lyophilized extract of Panax notoginseng roots, is extensively used in traditional Chinese medicine to treat ischemic heart and cerebrovascular diseases. Our recent study shows that treatment with XST inhibits shear-induced thrombosis formation but
Chemical gating of the mechanosensitive Piezo1 channel by asymmetric binding of its agonist Yoda1.
Lacroix JJ, et al.
bioRxiv, 169516-169516 (2017)
Jerome J Lacroix et al.
Nature communications, 9(1), 2029-2029 (2018-05-26)
Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction
Immacolata Andolfo et al.
American journal of hematology, 95(2), 188-197 (2019-11-19)
Dehydrated hereditary stomatocytosis (DHS), or xerocytosis, is an autosomal dominant hemolytic anemia. Most patients with DHS carry mutations in the PIEZO1 gene encoding a mechanosensitive cation channel. We here demonstrate that patients with DHS have low levels of hepcidin and
Erika Sugisawa et al.
Cell, 182(3), 609-624 (2020-07-09)
Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-hydroxytryptamine [5-HT]) production. A recent report suggested that gut microbes regulate 5-HT levels; however, the precise underlying molecular mechanisms are unexplored. Here, we reveal that the cation channel Piezo1 in
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