推荐产品
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 0.2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
[s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O
InChI key
QRLPSNLBUMVXBL-UHFFFAOYSA-N
应用
NMDI14作为mRNA无义介导降解(NMD)抑制剂的应用：
- 研究其对分化心肌细胞的影响
- 研究其对斑马鱼pdzk1基因敲除胚胎的影响
- 分析其对结直肠癌细胞凋亡的影响
生化/生理作用
NMDI14 是一种有效的无意义介导 RNA 衰变（NMD）抑制剂。 NMDI14 靶向 SMG7 蛋白的口袋，并破坏 SMG7-UPF1 相互作用。 NMDI14 可恢复具有提前终止密码子（PTC）突变的 p53 的细胞中的全长 p53 蛋白活性。
有效的无意义介导 RNA 衰变（NMD）抑制剂
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Michael Bordonaro et al.
Journal of Cancer, 10(2), 287-292 (2019-02-06)
Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD)
Greg H P Ngo et al.
Nature communications, 12(1), 3849-3849 (2021-06-24)
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures
Xinyun Chen et al.
Nature communications, 12(1), 89-89 (2021-01-06)
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki is found highly expressed in developing and adult hearts. By employing the human
Jiaheng Xie et al.
Investigative ophthalmology & visual science, 62(3), 29-29 (2021-03-23)
The human PDZK1 gene is located in a genomic susceptibility region for neurodevelopmental disorders. A genome-wide association study identified links between PDZK1 polymorphisms and altered visual contrast sensitivity, an endophenotype for schizophrenia and autism spectrum disorder. The PDZK1 protein is
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