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Merck
CN
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文件

安全信息

SML1523

Sigma-Aldrich

Estetrol

≥98% (HPLC)

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别名:
15α-Hydroxyestriol, 3,15α,16α,17β-Tetrahydroxyestra-1,3,5(10)-triene, E4, Estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol, Oestetrol
经验公式（希尔记法）:
C18H24O4
CAS号:
15183-37-6
分子量:
304.38
MDL编号:
MFCD00198996
UNSPSC代码:
12352200
PubChem化学物质编号:
329825940
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

SMILES字符串

[H][C@@]12CCC3=CC(O)=CC=C3[C@@]1([H])CC[C@@]4(C)[C@@]2([H])[C@@H](O)[C@@H](O)[C@@H]4O

InChI

1S/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12-,13-,14-,15-,16-,17+,18+/m1/s1

InChI key

AJIPIJNNOJSSQC-NYLIRDPKSA-N

一般描述

Estetrol is an estrogenic steroid molecule produced exclusively during pregnancy by the fetal liver.

生化/生理作用

Estetrol (E4, 15α-Hydroxyestriol) is an estrogen steroid hormone produced exclusively during pregnancy by the fetal liver. Estetrol is a selective estrogen receptor modulator (SERM) with potent estrogenic effects on vaginal mucosa, bone and brain, neutral effect on liver, and anti-estrogen effects on breast tissue. Estetrol has higher affinity for ERα over ERβ. Estetrol is being studied for its potential as a contraceptive, a drug for meopausal symptoms, and an anticancer agent.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Christian F Holinka et al.
The Journal of steroid biochemistry and molecular biology, 110(1-2), 138-143 (2008-05-09)
Estetrol (E(4)) is an estrogenic steroid molecule synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta. Its function is presently unknown. After its discovery in the mid-1960s, E(4) research revealed rather unique

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