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Merck
CN
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文件

安全信息

SML1506

Sigma-Aldrich

KY-05009

≥98% (HPLC)

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别名:
5-(4-Methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide, 5-[(4-Methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide
经验公式（希尔记法）:
C18H16N4O2S
CAS号:
1228280-29-2
分子量:
352.41
UNSPSC代码:
12352200
PubChem化学物质编号:
329825926
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

light yellow to dark yellow

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES字符串

NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O

InChI

1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)

InChI key

WCEDGRTWDSHZHF-UHFFFAOYSA-N

生化/生理作用

KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells
Lee Y, et al.
Oncotarget, 8(25), 41091-41091 (2017)

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