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Merck
CN
所有图片(1)

文件

SML1502

Sigma-Aldrich

吡唑啉

≥98% (HPLC)

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别名:
4-羟基-5- β-D-呋喃呋喃糖基-1H-吡唑-3-羧酰胺, 吡唑啉, 吡唑霉素
经验公式（希尔记法）:
C9H13N3O6
CAS号:
30868-30-5
分子量:
259.22
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D -49 to -39°, c = 0.5 in H2O

颜色

white to light brown

溶解性

H2O: 5 mg/mL, clear (warmed)

储存温度

−20°C

SMILES字符串

O[C@H]1[C@@H](O)[C@H](C2=NNC(C(N)=O)=C2O)O[C@@H]1CO

InChI

1S/C9H13N3O6/c10-9(17)4-6(15)3(11-12-4)8-7(16)5(14)2(1-13)18-8/h2,5,7-8,12-14,16-17H,1,10H2/b9-4-/t2-,5-,7-,8+/m1/s1

InChI key

CUVZEMGCUKKNOR-LNTXVZDSSA-N

生化/生理作用

吡唑呋喃菌素是一种乳清酸核苷-5'-单磷酸脱羧酶（ODCase，OMP 脱羧酶）抑制剂，具有有效的抗病毒、抗疟疾和锥虫活性。
吡唑呋林可作为抗 HIV（人类免疫病毒）、牛痘病毒、西尼罗河病毒感染的有效药物。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Generation of predictive pharmacophore model for SARS-coronavirus main proteinase.
Zhang X W, et al.
European Journal of Medicinal Chemistry, 40(1), 57-62 (2005)
M C Georges-Courbot et al.
Antimicrobial agents and chemotherapy, 50(5), 1768-1772 (2006-04-28)
Clinical nonrandomized trials demonstrate some efficacy for ribavirin in the treatment of patients with severe Nipah virus-induced encephalitis. We report here that EICAR, the 5-ethynyl analogue of ribavirin, and the OMP-decarboxylase inhibitors 6-aza-uridine and pyrazofurin have strong antiviral activity against
Maria Elena Meza-Avina et al.
Bioorganic & medicinal chemistry, 18(11), 4032-4041 (2010-05-11)
In recent years, orotidine-5'-monophosphate decarboxylase (ODCase) has gained renewed attention as a drug target. As a part of continuing efforts to design novel inhibitors of ODCase, we undertook a comprehensive study of potent, structurally diverse ligands of ODCase and analyzed
Guangyan Kan et al.
Journal of translational medicine, 19(1), 161-161 (2021-04-22)
Lung cancer is one of the most widely spread cancers in the world and half of the non-small cell lung cancers are lung adenocarcinoma (LUAD). Although there were several drugs been approved for LUAD therapy, a large portion of LUAD
Han B Ong et al.
Molecular microbiology, 90(2), 443-455 (2013-08-29)
African trypanosomes are capable of both de novo synthesis and salvage of pyrimidines. The last two steps in de novo synthesis are catalysed by UMP synthase (UMPS) - a bifunctional enzyme comprising orotate phosphoribosyl transferase (OPRT) and orotidine monophosphate decarboxylase

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