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CN
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安全信息

SML1476

Sigma-Aldrich

Thiocolchicoside

≥98% (HPLC)

别名:

(S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine

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About This Item

经验公式（希尔记法）:
C27H33NO10S
CAS号:
602-41-5
分子量:
563.62
EC 号:
210-017-7
MDL编号:
MFCD07995056
UNSPSC代码:
12352200
PubChem化学物质编号:
329825907
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D -510 to -610°, c = 0.5 in H2O

颜色

light yellow to dark yellow

溶解性

H2O: 10 mg/mL, clear

储存温度

−20°C

SMILES字符串

O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O

InChI

1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1

InChI key

LEQAKWQJCITZNK-AXHKHJLKSA-N

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生化/生理作用

Thiocolchicoside acts as a muscle relaxant. In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol. Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones.
Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity.
Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

预防措施声明

P201 - P301 + P310 + P330

危险分类

Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1

靶器官

Gastro-intestinal system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000359114
0000359115
0000359115
0000359114
0000151053

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Thiocolchicoside: review of adverse effects.
Prescrire International, 25(168), 3-41 (2016)
Impact of using thiocolchicoside during endoscopic ureteral calculi removal: A preliminary study.
Akin Y, et al.
Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy, 25(1), 29-34 (2016)

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