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质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D -510 to -610°, c = 0.5 in H2O
颜色
light yellow to dark yellow
溶解性
H2O: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
InChI
1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
InChI key
LEQAKWQJCITZNK-AXHKHJLKSA-N
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生化/生理作用
Thiocolchicoside acts as a muscle relaxant. In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol. Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones.
Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.
警示用语:
Danger
危险分类
Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
靶器官
Gastro-intestinal system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Impact of using thiocolchicoside during endoscopic ureteral calculi removal: A preliminary study.
Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy, 25(1), 29-34 (2016)
Thiocolchicoside: review of adverse effects.
Prescrire International, 25(168), 3-41 (2016)
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