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Merck
CN
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文件

SML1426

Sigma-Aldrich

Gap19 trifluoroacetate salt

≥95% (HPLC)

别名:

KQIEIKKFK trifluoroacetate salt, L-lLysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl--L-lysine, Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Ly trifluoroacetate salt

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About This Item

经验公式（希尔记法）:
C55H96N14O13 · xC2HF3O2
CAS号:
1507930-57-5
分子量:
1161.44 (free base basis)
UNSPSC代码:
12352202
NACRES:
NA.77

质量水平

100

检测方案

≥95% (HPLC)

形式

powder

颜色

white to off-white

运输

wet ice

储存温度

−20°C

InChI

1S/C55H96N14O13/c1-5-33(3)45(69-51(77)40(25-27-44(71)72)65-54(80)46(34(4)6-2)68-50(76)39(24-26-43(61)70)62-47(73)36(60)20-10-14-28-56)53(79)64-38(22-12-16-30-58)48(74)63-37(21-11-15-29-57)49(75)67-42(32-35-18-8-7-9-19-35)52(78)66-41(55(81)82)23-13-17-31-59/h7-9,18-19,33-34,36-42,45-46H,5-6,10-17,20-32,56-60H2,1-4H3,(H2,61,70)(H,62,73)(H,63,74)(H,64,79)(H,65,80)(H,66,78)(H,67,75)(H,68,76)(H,69,77)(H,71,72)(H,81,82)/t33-,34-,36-,37-,38-,39-,40-,41-,42-,45-,46-/m0/s1

InChI key

IEAKEKFIXUZWEH-PKMKMBMKSA-N

应用

Gap19 trifluoroacetate salt has been used to inhibit Ca2+/calmodulin (CaM) gating response of connexin 43 (Cx43) gap junctions.

生化/生理作用

Gap19, nonapeptide from the cytoplasmic loop of Connexin-43, is a selective blocker of connexin 43 (Cx43) hemichannel that does not block GJ or Cx40/Panx-1 channels in cardiomyocytes and astrocytes. Gap19 prevents Cx43 hemichannel opening and protect against myocardial ischemia/reperfusion injury.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Calcium-Calmodulin Gating of Connexin43 Gap Junctions in the Absence of the pH Gating Domain.
Veenstra R D.
bioRxiv, 311613-311613 (2018)

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