推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: ≥10 mg/mL, clear
储存温度
−20°C
SMILES字符串
CS(C(C=C1)=CC=C1C2=NC(C(NC3=CC=CC=C3)=O)=C(N)N=C2)(=O)=O
InChI
1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23)
InChI key
DUIHHZKTCSNTGM-UHFFFAOYSA-N
应用
VE-821 已用作人癌细胞中 ATM 和 Rad3 相关（ATR）蛋白的抑制剂。
生化/生理作用
VE-821 是一种有效的 ATP 竞争性抑制剂，可抑制 DNA 损伤应答（DDR）激酶共济失调毛细血管扩张突变（ATM）以及与 ATM 和 Rad3 相关（ATR），Ki 值为 13 nM。VE-821 对相关 PIKKs ATM、DNA 依赖性蛋白激酶（DNA-PK）、mTOR 和 PI3-激酶-γ 的交叉反应极小（Ki 值分别为 16 μM、2.2 μM、>1 μM 和 3.9 μM），并针对大量无关的蛋白激酶。在大部分癌细胞中单独使用 VE-821 会导致细胞死亡，并且还显示出与遗传毒性剂的强大协同作用。VE-821 增加了细胞对放射线的敏感性，并使癌细胞对多种化学治疗剂敏感。
其他说明
VE-821 已由化学探针门户网站进行了专家审查和推荐。有关更多信息，请访问化学探针门户网站上的 VE-821 探针摘要。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Tingting Li et al.
Aging, 12(14), 14791-14807 (2020-07-21)
Protection of telomere 1 (POT1), the telomeric single-stranded DNA (ssDNA)-binding protein in the shelterin complex, has been implicated in the DNA damage response, tumorigenesis and aging. Telomere dysfunction induced by telomere deprotection could accelerate cellular senescence in primary human cells.
Anastazja Poczta et al.
Scientific reports, 9(1), 14135-14135 (2019-10-03)
The present study investigated the effect of cladribine (CLA) and six of its derivatives containing a formamidine group at position 6 (CLA-FDM, CLA-FPAZ, CLA-FPIR, CLA-FPIP, CLA-FHEX, and CLA-FMOR) on acute promyelocytic, lymphoblastic, and acute monocytic leukemia cells. The role of
Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism
Ozgun Ozer, et al.
Oncotarget null
Aldo S Bader et al.
Nature communications, 14(1), 8419-8419 (2023-12-19)
DNA double-strand breaks (DSBs) are the most mutagenic form of DNA damage, and play a significant role in cancer biology, neurodegeneration and aging. However, studying DSB-induced mutagenesis is limited by our current approaches. Here, we describe iMUT-seq, a technique that
Yoichiro Harada et al.
eLife, 12 (2023-07-18)
Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of chemotherapy. How mannose exerts its anticancer activity, however, remains poorly understood. Here, using genetically engineered human cancer cells that permit the precise control of mannose metabolic flux
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