所有图片(1)
别名:
2-[（（7-甲氧基-4-甲基-2-喹唑啉基）氨基] -5,6-二甲基-4（1H）-嘧啶酮（9CI）, 2-（7-甲氧基-4-甲基-喹唑啉-2-基氨基）-5,6-二甲基-3H-嘧啶-4-酮, 4（1H）-嘧啶酮，2-[（（7-甲氧基-4-甲基-2-喹唑啉基）氨基] -5,6-二甲基-（9CI）, 4（3H）-嘧啶酮，2-[（（7-甲氧基-4-甲基-2-喹唑啉基）氨基] -5,6-二甲基-, DDD00107587, RNA剪接抑制剂
经验公式（希尔记法）:
C16H17N5O2
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
, white to dark brown
溶解性
DMSO: 0.5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
CC1=NC(NC(NC(C)=C2C)=NC2=O)=NC3=CC(OC)=CC=C31
InChI
1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
InChI key
QQJIYKXTEMDJFM-UHFFFAOYSA-N
应用
Madrasin已作为剪接体抑制剂，抑制3T3-L1细胞中前体RNA的剪接加工。
生化/生理作用
Madrasin 是一种高效的、细胞渗透性剪接抑制剂，可干扰剪接体组装的早期阶段。 Madrasin 使 A 复合体的剪接体装配停滞。
Madrasin在较高浓度下具有细胞毒性。在极低浓度下，Madrasin可诱导蛋白亚细胞核定位和引起细胞周期停滞。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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The Journal of biological chemistry, 289(50), 34683-34698 (2014-10-05)
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