SML1394
奥美沙坦
≥98% (HPLC), Angiotensin II Type I receptor blocker, powder
别名:
4-（1-羟基-1-甲基乙基）-2-丙基-1- [ [2′--（2H-四唑-5-基） [1,1′--联苯 ]-4-基 ] 甲基 ]-1H-咪唑-5-羧酸, 奥美沙坦酸
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关于此项目
经验公式（希尔记法）:
C24H26N6O3
化学文摘社编号:
分子量:
446.50
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
奥美沙坦, ≥98% (HPLC)
SMILES string
OC(C)(C)C1=C(C(O)=O)N(CC2=CC=C(C3=C(C4=NNN=N4)C=CC=C3)C=C2)C(CCC)=N1
InChI
1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)
InChI key
VTRAEEWXHOVJFV-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Gene Information
human ... AGTR1(185)
相关类别
Application
奥美沙坦已用作血管紧张素 II 受体 1（AT1） 的受体抑制剂，用于研究血管紧张素 II 1 型受体相互作用在调节血管紧张素 II 依赖性高血压中肾传入小动脉的作用。
Biochem/physiol Actions
奥美沙坦具有抗炎和抗氧化应激特性。它保护神经元细胞免于低聚淀粉样蛋白β（Aβ）诱导的细胞衰老。
奥美沙坦是一种血管紧张素 ⅡⅠ 型受体阻滞剂。
奥美沙坦是一种血管紧张素 ⅡⅠ 型受体阻滞剂。奥美沙坦是降压药奥美沙坦酯的活性形式。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Mi-Yeon Yu et al.
PloS one, 13(8), e0202676-e0202676 (2018-08-28)
Albuminuria is a predictor of disease progression in patients with chronic kidney disease (CKD). However, the ability of proteinuria parameters measured at various time periods to predict renal outcomes is unclear. This observational cohort study included 165 non-diabetic hypertensive CKD
Bapi Gorain et al.
Regulatory toxicology and pharmacology : RTP, 82, 20-31 (2016-11-07)
Poor aqueous solubility and unfavourable de-esterification of olmesartan medoxomil (a selective angiotensin II receptor blocker), results in low oral bioavailability of less than 26%. Improvement of oral bioavailability with prolonged pharmacodynamics activity of olmesartan in Wistar rats had been approached
C Custodero et al.
Ageing research reviews, 46, 42-59 (2018-05-29)
Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism underlying the aging process. Some biological and pharmaceutical compounds may reduce systemic inflammation and potentially avert functional decline occurring with aging. The aim of the present meta-analysis was to
Nanako Muraya et al.
Oxidative medicine and cellular longevity, 2018, 7635274-7635274 (2018-07-04)
Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce oxidative stress to treat hyperuricemia. We
Elham Bakhtiari et al.
Toxicology mechanisms and methods, 25(8), 614-621 (2015-09-04)
Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce the proliferation of cancer cells. The role of NF-κB pathway has
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