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质量水平
方案
≥98% (HPLC)
表单
powder (flocculent)
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3
InChI
1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)
InChI key
ZATJMMZPGVDUOM-UHFFFAOYSA-N
生化/生理作用
FDI-6是FOXM1的一种有效且特异性抑制剂,其可可阻止DNA的结合。FDI-6可与FOXM1蛋白结合,并特异性下调FOXM1激活的基因。
叉头结构域抑制剂6(FDI-6)可用于治疗因血液生成减少而导致贫血的患者。在Hep-2细胞中,FDI-6可以刺激细胞死亡,还有助于防止细胞增殖、侵袭和迁移。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种:
分析证书(COA)
Cancer cell, 38(4), 516-533 (2020-09-26)
PIK3CA, encoding the PI3Kα isoform, is the most frequently mutated oncogene in estrogen receptor (ER)-positive breast cancer. Isoform-selective PI3K inhibitors are used clinically but intrinsic and acquired resistance limits their utility. Improved selection of patients that will benefit from these
Nature communications, 11(1), 4678-4678 (2020-09-18)
Diabetic foot ulcers (DFUs) are a life-threatening disease that often result in lower limb amputations and a shortened lifespan. However, molecular mechanisms contributing to the pathogenesis of DFUs remain poorly understood. We use next-generation sequencing to generate a human dataset
Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1
Chinese Journal of Catalysis, 33(5), 611-616 (2017)
Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors
Haematologica, 102(5), 826-834 (2017)
International journal of molecular sciences, 22(13) (2021-07-03)
Triple-negative breast cancer (TNBC) presents an important clinical challenge, as it does not respond to endocrine therapies or other available targeting agents. FOXM1, an oncogenic transcriptional factor, has reported to be upregulated and associated with poor clinical outcomes in TNBC
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