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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 20 mg/mL, clear
储存温度
−20°C
SMILES字符串
OB(O)CCSC[C@H](N)C(O)=O.C
InChI
1S/C5H12BNO4S.CH4/c7-4(5(8)9)3-12-2-1-6(10)11;/h4,10-11H,1-3,7H2,(H,8,9);1H4/t4-;/m0./s1
InChI key
IMYJQAMXIIYUIH-WCCKRBBISA-N
生化/生理作用
BEC 是 L-精氨酸和 L-半胱氨酸的硼类似物。它竞争性地抑制精氨酸酶 I 和 II。BEC 不会直接影响一氧化氮合酶。
BEC（S-（2-硼烷乙基）-L-半胱氨酸）是一种有效的和特异性精氨酸酶抑制剂，可恢复糖尿病大鼠小动脉中血流诱导的应答。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension
Johnson FK, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 288(4), R1057-R1062 (2005)
Amino Acids in Human Nutrition and Health, 62-62 (2012)
Alessandra Romano et al.
Expert review of molecular diagnostics, 18(7), 675-683 (2018-05-01)
Despite improvement in overall response due to the introduction of the first-in-class proteasome inhibitor bortezomib (btz), multiple myeloma (MM) is still an incurable disease due to the immune-suppressive bone marrow (BM) environment. Thus, the authors aimed to identify the role
Barbara Érsek et al.
Cellular and molecular life sciences : CMLS, 78(2), 661-673 (2020-04-25)
This study shows that melanoma-associated fibroblasts (MAFs) suppress cytotoxic T lymphocyte (CTL) activity and reveals a pivotal role played by arginase in this phenomenon. MAFs and normal dermal fibroblasts (DFs) were isolated from surgically resected melanomas and identified as Melan-A-/gp100-/FAP+ cells.
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