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Merck
CN

SML1379

Sigma-Aldrich

Seratrodast

≥98% (HPLC)

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别名:
(±)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid, AA-2414
经验公式(希尔记法):
C22H26O4
分子量:
354.44
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 25 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C(C(C)=C1C)C(C)=C(C(CCCCCC(O)=O)C2=CC=CC=C2)C1=O

InChI

1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24)

InChI key

ZBVKEHDGYSLCCC-UHFFFAOYSA-N

基因信息

human ... TBXA2R(6915)

生化/生理作用

Seratrodast is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist with anti-asthmatic activity. Seratrodast inhibits the bronchconstriction induced by leukotriene D4 (LTD4), and platelet activating factor (PAF) with a long duration of action.

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Margarita Rosa Romero-Imbachi et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 240, 108939-108939 (2020-11-10)
Centruroides margaritatus scorpion stings are common in Colombia. However, the cardiovascular toxicity of the venom has not been clarified. To study the effect and mechanisms of action of the complete venom of C. margaritatus (CmV) on the murine cardiovascular system.

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