质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC1=CC=C(OC[C@@H](O)CNCCC2=CC=C(NS(C3=CC=C(NC(NCCCCCC)=O)C=C3)(=O)=O)C=C2)C=C1
InChI
1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1
InChI key
NYYJKMXNVNFOFQ-MHZLTWQESA-N
一般描述
L755507是4-酰基氨基苯磺酰胺的一种衍生物。
应用
L755507显示出具有提高CRISPR基因组编辑效率的作用。欲了解其他CRISPR增强剂小分子，请访问 sigma.com/CRISPR-enhancers。
生化/生理作用
L755507可以激活人脂肪组织脂解。L755507也促进膀胱松弛。
L755507是一种有效的β3-肾上腺素能受体部分激动剂。
L755507是一种有效的β3-肾上腺素能受体部分激动剂，对β3受体的EC50值为0.43 nM，对β3的选择性相比β1和β2肾上腺素能受体结合高出440倍。L755507增强人诱导多能干细胞(iPSCs)中CRISPR介导的同源重组修复(HDR)效率，GFP插入效率相比对照细胞增加了2倍。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Dana S Hutchinson et al.
British journal of pharmacology, 135(8), 1903-1914 (2002-04-18)
1. This study characterizes the mouse beta(3a)-adrenoceptor (AR) and the splice variant of the beta(3)-AR (beta(3b)-AR) expressed in Chinese hamster ovary cells (CHO-K1). 2. Stable clones with high (approximately 1200), medium (approximately 500) or low receptor expression (approximately 100 fmol
Tools to study β 3-adrenoceptors.
Vrydag W and Michel M C
Naunyn-Schmiedeberg'S Archives of Pharmacology, 374(5-6), 385-398 (2007)
E R Parmee et al.
Bioorganic & medicinal chemistry letters, 8(9), 1107-1112 (1999-01-01)
A study of 4-acylaminobenzenesulfonamides in a cloned human beta 3 adrenergic receptor assay resulted in the discovery of n-hexylurea, L-755,507 (22). This 0.43 nM beta 3 agonist, which is > 440-fold selective over both beta 1 and beta 2 binding
Masaaki Sato et al.
Molecular pharmacology, 74(5), 1417-1428 (2008-08-08)
This study identifies signaling pathways activated by the beta(2)-/beta(3)-adrenoceptor (AR) agonist zinterol, the selective beta(3)-AR agonist L755507, and the selective beta(3)-AR antagonist L748337 in CHO-K1 cells expressing human beta(3)-adrenoceptors. Zinterol and L755507 caused a robust concentration-dependent increase in cAMP accumulation
Ashutosh Singh et al.
The Journal of biological chemistry, 297(1), 100903-100903 (2021-06-23)
c-Myc is a transcription factor that plays a crucial role in cellular homeostasis, and its deregulation is associated with highly aggressive and chemotherapy-resistant cancers. After binding with partner MAX, the c-Myc-MAX heterodimer regulates the expression of several genes, leading to
商品
业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。
Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.
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