SML1355
PHTPP
≥98% (HPLC), estrogen receptor β antagonist, powder
别名:
2-苯基-3-（4-羟基苯基）-5,7-双（三氟甲基）-吡唑并[1,5-a] 嘧啶, 4-[2-苯基-5,7-双（三氟甲基）吡唑并[1,5-a]-嘧啶-3-基] 苯酚
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关于此项目
经验公式（希尔记法）:
C20H11F6N3O
化学文摘社编号:
分子量:
423.31
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
PHTPP, ≥98% (HPLC)
Quality Level
storage temp.
2-8°C
SMILES string
OC(C=C1)=CC=C1C(C(C2=CC=CC=C2)=N3)=C4N3C(C(F)(F)F)=CC(C(F)(F)F)=N4
InChI key
AEZPAUSGTAHLOQ-UHFFFAOYSA-N
InChI
1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 5 mg/mL, clear (warmed)
相关类别
Biochem/physiol Actions
PHTPP 也被称为 4-[2-苯基-5,7-双（三氟甲基）吡唑并 [1,5- a -嘧啶-3-基] 苯酚 (PHTPP)。阻断下丘脑弓状核 (ARH) 内去甲肾上腺素 (NE) 的低血糖增强作用。
PHTPP是一种选择性雌激素受体β（ERβ）完全拮抗剂。
PHTPP是选择性雌激素受体β（ERβ）全拮抗剂，对ERβ的选择性是ERα的36倍。PHTPP已被用作区分两种雌激素受体的各种活性。与ERβ比例，雌激素在一些表达ERα的肿瘤中可以产生相反的作用，ERα增强和ERβ抑制肿瘤细胞生长。PHTPP是一种选择性的ERβ拮抗剂，可显着促进同时表达两个受体的克罗地亚纳米级SKOV3和OV2008的细胞生长。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Briski KP and Shrestha PK
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