产品名称
谷氨酰胺酶抑制剂968, ≥98% (HPLC)
SMILES string
Brc1c(ccc(c1)C2Nc3c(c5c(cc3)cccc5)C4=C2C(=O)CC(C4)(C)C)N(C)C
InChI
1S/C27H27BrN2O/c1-27(2)14-19-24-18-8-6-5-7-16(18)9-11-21(24)29-26(25(19)23(31)15-27)17-10-12-22(30(3)4)20(28)13-17/h5-13,26,29H,14-15H2,1-4H3
InChI key
NVFRRJQWRZFDLM-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
相关类别
Application
谷氨酰胺酶抑制剂968已被用于研究谷氨酰胺代谢在巨噬细胞活化中的作用。
Biochem/physiol Actions
谷氨酰胺酶抑制剂968在其3-溴-4-（二甲基氨基）苯环上的变化会导致其抑制活性的丧失。 谷氨酰胺酶催化的谷氨酰胺代谢可维持癌细胞的细胞内pH。谷氨酰胺酶抑制剂968的抑制会导致低细胞内pH，从而阻碍细胞增殖。
谷氨酰胺酶抑制剂968是一种线粒体酶谷氨酰胺酶C（GAC）的变构抑制剂。
谷氨酰胺酶抑制剂968是一种线粒体酶谷氨酰胺酶C（GAC）的变构抑制剂，该酶在许多癌细胞系中过表达。谷氨酰胺酶抑制剂968在10μM下显示出21％的抑制，在25μM下显示出94％的抑制。谷氨酰胺酶抑制剂968可阻止人类癌细胞在培养物中的增殖，并在小鼠异种移植模型中可抑制肿瘤的形成。
General description
谷氨酰胺酶抑制剂968属于二苯并菲啶酮家族。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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