生化/生理作用
HS-72 is a cell permeable, highly selective allosteric inhibitor of inducible Hsp70 (Hsp70i) over constitutively active Hsc70. HS-72 inhibits cancer cell proliferation and promotes a survival in a HER2+ mouse model of breast cancer.
HS-72 is also termed as ((S)-N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide). It is considered as a powerful anti-dengue virus (DENV) therapeutic agent. It displays anti-DENV activity in monocyte and liver cell lines. HS-72 stimulates the accumulation of cellular proteins.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target
Howe M K, et al.
Antiviral Research, 130, 81-92 (2016)
Matthew K Howe et al.
Chemistry & biology, 21(12), 1648-1659 (2014-12-17)
Inducible Hsp70 (Hsp70i) is overexpressed in a wide spectrum of human tumors, and its expression correlates with metastasis, poor outcomes, and resistance to chemotherapy in patients. Identification of small-molecule inhibitors selective for Hsp70i could provide new therapeutic tools for cancer
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门