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安全和法规

SML1279

LLY-507

Name: LLY-507
Brand: SIGMA

≥97% (HPLC)

别名:

5-Cyano-2′-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide

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About This Item

经验公式（希尔记法）:

C₃₆H₄₂N₆O

CAS号:

1793053-37-8

分子量:

574.76

UNSPSC代码:

51111800

PubChem化学物质编号:

329825763

NACRES:

NA.77

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Sigma-Aldrich

5.31661

SMYD2 抑制剂，AZ505

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219478

Cdk4 Inhibitor III

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SML0720

醋甲唑胺

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SML1072

GSK-LSD1

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218696

Casein Kinase I Inhibitor, D4476

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SML1603

BAY-598

Sigma-Aldrich

R2625

视黄酸

Sigma-Aldrich

361554

GSK-3β抑制剂XII, TWS119

Sigma-Aldrich

F114

顺式-(Z)-氟噻唑二盐酸盐

Sigma-Aldrich

SML0352

PFI-1

质量水平

100

方案

≥97% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

CC(C1=C2C=CC=C1)=CN2CCN(CC3)CCN3C4=CC=CC=C4C5=CC(C#N)=CC(C(NCCCN6CCCC6)=O)=C5

InChI

1S/C36H42N6O/c1-28-27-42(34-11-4-2-9-32(28)34)22-19-40-17-20-41(21-18-40)35-12-5-3-10-33(35)30-23-29(26-37)24-31(25-30)36(43)38-13-8-16-39-14-6-7-15-39/h2-5,9-12,23-25,27H,6-8,13-22H2,1H3,(H,38,43)

InChI key

PNYRDVBFYVDJJI-UHFFFAOYSA-N

生化/生理作用

LLY-507 is a potent and selective inhibitor of SMYD2 protein lysine methyltransferase (PKMT) with an in vitro IC₅₀ <15 nM and >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC₅₀ ~600 nM. For full characterization details, please visit the LLY-507 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

LLY-507 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他说明

LLY-507 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the LLY-507 probe summary on the Chemical Probes Portal website.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

045M4617V

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Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling.

Xiaolan Deng et al.

Oncotarget, 8(34), 55837-55847 (2017-09-17)

Accumulation of β-catenin in the nucleus is a hallmark of activation of the Wnt/β-catenin signaling pathway, which drives development of a large proportion of human cancers. However, the mechanism of β-catenin nuclear translocation has not been well investigated. Here we

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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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LLY-507

≥97% (HPLC)

About This Item

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储存分类代码

WGK

闪点(°F)

闪点(°C)

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分析证书(COA)

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