推荐产品
生物来源
Streptomyces hygroscopicus
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
protect from light
颜色
yellow to yellow-orange
溶解性
DMSO: soluble 5 mg/mL
抗生素抗菌谱
neoplastics
作用机制
enzyme | inhibits
储存温度
−20°C
相关类别
一般描述
Chemical structure: benzenoid
生化/生理作用
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Dora Posfai et al.
Antimicrobial agents and chemotherapy, 62(4) (2018-01-18)
Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an essential protein for blood-stage Plasmodium parasites, but details about its function during malaria's
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