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安全信息

SML1276

Sigma-Aldrich

BAZ2-ICR

≥98% (HPLC)

别名:

4-{4-(1-Methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)-ethyl]-1H-imidazol-5-yl}-benzonitrile

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5 MG
¥1,029.74

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¥1,029.74

About This Item

经验公式（希尔记法）:
C20H19N7
CAS号:
1665195-94-7
分子量:
357.41
MDL编号:
MFCD28166490
UNSPSC代码:
12352200
PubChem化学物质编号:
329825762
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES字符串

CN(N=C1)C=C1CCN2C=NC(C3=CN(C)N=C3)=C2C4=CC=C(C#N)C=C4

InChI

1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3

InChI key

RRZVGDGTWNQAPW-UHFFFAOYSA-N

相关类别

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CLS4830CLS4834CLS4826
Corning® microvolume pipet tips 0.1-10 μL, universal fit racked pipet tips, natural, sterile, 96 tips/rack, 960tips/case

CLS4894

Corning® microvolume pipet tips

Corning® microvolume pipet tips 0.5-10 μL, universal fit racked pipet tips, natural, sterile, 96 tips/rack, 960 tips/case

CLS4830

Corning® microvolume pipet tips

Corning® microvolume pipet tips 0.5-10 μL, universal fit racked pipet tips, natural, non-sterile, 96 tips/rack, 960 tips/case

CLS4834

Corning® microvolume pipet tips

Corning® microvolume pipet tips 0.1-10 μL, universal fit racked pipet tips, natural, non-sterile, 96 tips/rack, 960tips/case

CLS4826

Corning® microvolume pipet tips

sterility

sterile

sterility

sterile

sterility

non-sterile

sterility

non-sterile

manufacturer/tradename

Corning 4894

manufacturer/tradename

Corning 4830

manufacturer/tradename

Corning 4834

manufacturer/tradename

Corning 4826

material

natural tip, polypropylene

material

natural tip, polypropylene

material

natural tip, polypropylene

material

natural tip, polypropylene

packaging

rack of 96

packaging

rack of 96

packaging

rack of 96

packaging

rack of 96

volume range

0.1-10 μL

volume range

0.5-10 μL

volume range

0.5-10 μL

volume range

0.1-10 μL

生化/生理作用

BAZ2-ICR is a chemical probe for BAZ2A/B bromodomains with >100-fold selectivity over other bromodomains, with the exception of CECR2 (15-fold selectivity). BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifyine enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription by RNA polymerase I. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA. BAZ2-ICR binds to BAZ2A with a KD of 109 nM (ITC) and to BAZ2B with a KD of 170 nM (ITC). BAZ2-ICR also shows accelerated Fluorescence recovery after photobleaching (FRAP) recovery at 1 μM in the BAZ2A FRAP assay. For full characterization details, please visit the BAZ2-ICR probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
BAZ2-ICR is a chemical probe for BAZ2A/B bromodomains.

特点和优势

BAZ2-ICR is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他说明

BAZ2-ICR has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the BAZ2-ICR probe summary on the Chemical Probes Portal website.

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象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000419339
    0000419336
    0000419336
    0000419339
    0000218354

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    Samantha M Bevill et al.
    Molecular cancer research : MCR, 17(7), 1503-1518 (2019-04-20)
    Screening of an inhibitor library targeting kinases and epigenetic regulators identified several molecules having antiproliferative synergy with extraterminal domain (BET) bromodomain (BD) inhibitors (JQ1, OTX015) in triple-negative breast cancer (TNBC). GSK2801, an inhibitor of BAZ2A/B BDs, of the imitation switch
    Rodrigo Peña-Hernández et al.
    EMBO reports, 22(11), e53014-e53014 (2021-08-18)
    Prostate cancer (PCa) is one of the most prevalent cancers in men. Cancer stem cells are thought to be associated with PCa relapse. Here, we show that BAZ2A is required for PCa cells with a cancer stem-like state. BAZ2A genomic

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