所有图片(1)
About This Item
经验公式（希尔记法）:
C18H14N4O2
CAS号:
分子量:
318.33
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
InChI
1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI key
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
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应用
TWS119已被用作糖原合酶激酶3β（GSK-3β）GSK3β抑制剂。
生化/生理作用
TWS119可通过激活哺乳动物雷帕霉素靶标（mTOR）途径促进γδT细胞的存活和增殖。它还可以促进T细胞因子1（TCF1）的表达并调节细胞因子的生成。
TWS119是一种可以诱导胚胎干细胞（ESC）中神经生成的有效糖原合酶激酶3β（GSK-3β）抑制剂。
TWS119是一种有效的糖原合成酶激酶-3 β(GSK-3β) 抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Nurr1: A vital participant in the TLR4-NF-kappaB signal pathway stimulated by alpha-synuclein in BV-2 cells
Shao QH, et al.
Neuropharmacology, 144, 388-399 (2019)
Limin Gao et al.
Neuroreport, 35(3), 200-207 (2024-02-02)
Brain injury in preterm infants is a major cause of disability and mortality in children. GSK-3β is a common pathogenic factor for cognitive dysfunction and involves in neuronal proliferation and differentiation. However, GSK-3β affected neuronal differentiation and its molecular pathogenesis
Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer
Chen YQ, et al.
Experimental Cell Research, 362(1), 63-71 (2018)
Effects of Glycogen Synthase Kinase-3beta Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer
Tang YY, et al.
Journal of Immunotherapy, 41(7), 319-319 (2018)
Yeonhwa Song et al.
Scientific reports, 14(1), 115-115 (2024-01-04)
Hepatocellular carcinoma (HCC) is a complex disease associated with a plethora of environmental and genetic/hereditary causative risk factors, more so than other oncological indications. Additionally, patients with HCC exhibit fibrosis, cirrhosis, and liver-related disease. This complicated etiology can affect the
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