推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
InChI
1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI key
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
应用
TWS119已被用作糖原合酶激酶3β(GSK-3β)GSK3β抑制剂。
生化/生理作用
TWS119可通过激活哺乳动物雷帕霉素靶标(mTOR)途径促进γδT细胞的存活和增殖。它还可以促进T细胞因子1(TCF1)的表达并调节细胞因子的生成。
TWS119是一种可以诱导胚胎干细胞(ESC)中神经生成的有效糖原合酶激酶3β(GSK-3β)抑制剂。
WGK
WGK 3
Effects of Glycogen Synthase Kinase-3beta Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer
Journal of Immunotherapy, 41(7), 319-319 (2018)
Nurr1: A vital participant in the TLR4-NF-kappaB signal pathway stimulated by alpha-synuclein in BV-2 cells
Neuropharmacology, 144, 388-399 (2019)
Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer
Experimental Cell Research, 362(1), 63-71 (2018)
International immunopharmacology, 85, 106577-106577 (2020-05-24)
Chemokine-like factor 1 (CKLF1) is a chemokine increased significantly in ischemic brain poststroke. It shows chemotaxis effects on various immune cells, but the mechanisms of CKLF1 migrating neutrophils are poorly understood. Recent studies have provided evidence that CC chemokine receptor
Archives of biochemistry and biophysics, 694, 108612-108612 (2020-10-03)
Apoptotic and inflammatory pathways play important roles in Mycobacterium tuberculosis-infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in mammalian cells and was recently reported to regulate mycobacterial immunopathogenesis via inflammatory responses.
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门