SML1265
波生坦 水合物
≥98% (HPLC), endothelin receptor antagonist, powder
别名:
4-(1,1-二甲基乙基)-N-[6-(2-羟基乙氧基)-5-(2-甲氧基苯氧基)[2,2′-联嘧啶]-4-基]-苯磺酰胺 一水合物, 4-叔丁基-N- [6-(2-羟基乙氧基)-5-(2-甲氧基-苯氧基)-[2,2´]-联嘧啶-4-基]-苯磺酰胺 一水合物, Ro-47-0203
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C27H29N5O6S · H2O
化学文摘社编号:
分子量:
569.63
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
波生坦 水合物, ≥98% (HPLC)
SMILES string
O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC(C3=NC=CC=N3)=NC(OCCO)=C2OC4=CC=CC=C4OC)=O.O
InChI
1S/C27H29N5O6S.H2O/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24;/h5-15,33H,16-17H2,1-4H3,(H,30,31,32);1H2
InChI key
SXTRWVVIEPWAKM-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
相关类别
Application
水合波生坦已用于细胞活力测定。此外，它还被用作钙瞬态分析的阳性对照。
Biochem/physiol Actions
已有发现证明，波生坦可减少肺中胶原蛋白沉积——在博来霉素诱导的肺纤维化大鼠模型中观察到此现象。
波生坦是一种内皮素受体拮抗剂。内皮素是一种有效的血管收缩药，因而成为治疗血管痉挛相关疾病（如蛛网膜下腔出血 (SAH) 和高血压）的临床关注拮抗剂。波生坦是一种双重内皮素受体拮抗剂，可有效治疗肺动脉高压(PAH)，这是首个投放市场的同类产品。波生坦是 ETA 和 ETB 受体亚型（ETA 的 Ki 为4.7 nM，ETB 的 Ki为95 nM）的竞争性口服拮抗剂。
波生坦是一种内皮素受体拮抗剂；降压；肺动脉高压治疗。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis.
King Jr T E, et al.
American Journal of Respiratory and Critical Care Medicine, 177(1), 75-81 (2008)
Endothelin-1 receptor blockade as new possible therapeutic approach in multiple myeloma.
Russignan A, et al.
British Journal of Haematology, 178(5), 781-793 (2017)
Molecular phenotyping combines molecular information, biological relevance, and patient data to improve productivity of early drug discovery.
Drawnel F M, et al.
Cell Chemical Biology, 24(5), 624-634 (2017)
Xiaomin Liang et al.
Drug metabolism and disposition: the biological fate of chemicals, 48(12), 1283-1292 (2020-10-11)
It is well documented that human hepatic clearance based on in vitro metabolism or transporter assays systematically resulted in underprediction; therefore, large empirical scalars are often needed in either static or physiologically based pharmacokinetic (PBPK) models to accurately predict human
Fuhua Yang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 170(1), 95-108 (2019-04-16)
The bile salt export pump (BSEP, ABCB11) mediates bile acid efflux from hepatocytes into bile. Although the inhibition of BSEP has been implicated as an important mechanism of drug-induced liver injury (DILI), liver injury caused by BSEP-inhibiting drugs is rarely
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持