质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC(C3=NC=CC=N3)=NC(OCCO)=C2OC4=CC=CC=C4OC)=O.O
InChI
1S/C27H29N5O6S.H2O/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24;/h5-15,33H,16-17H2,1-4H3,(H,30,31,32);1H2
InChI key
SXTRWVVIEPWAKM-UHFFFAOYSA-N
应用
水合波生坦已用于细胞活力测定。此外,它还被用作钙瞬态分析的阳性对照。
生化/生理作用
已有发现证明,波生坦可减少肺中胶原蛋白沉积——在博来霉素诱导的肺纤维化大鼠模型中观察到此现象。
波生坦是一种内皮素受体拮抗剂。内皮素是一种有效的血管收缩药,因而成为治疗血管痉挛相关疾病(如蛛网膜下腔出血 (SAH) 和高血压)的临床关注拮抗剂。波生坦是一种双重内皮素受体拮抗剂,可有效治疗肺动脉高压(PAH),这是首个投放市场的同类产品。波生坦是 ETA 和 ETB 受体亚型(ETA 的 Ki 为4.7 nM,ETB 的 Ki为95 nM)的竞争性口服拮抗剂。
警示用语:
Warning
危险声明
危险分类
Aquatic Chronic 3 - Repr. 2
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Molecular phenotyping combines molecular information, biological relevance, and patient data to improve productivity of early drug discovery.
Cell Chemical Biology, 24(5), 624-634 (2017)
Drug metabolism and disposition: the biological fate of chemicals, 48(12), 1283-1292 (2020-10-11)
It is well documented that human hepatic clearance based on in vitro metabolism or transporter assays systematically resulted in underprediction; therefore, large empirical scalars are often needed in either static or physiologically based pharmacokinetic (PBPK) models to accurately predict human
Endothelin-1 receptor blockade as new possible therapeutic approach in multiple myeloma.
British Journal of Haematology, 178(5), 781-793 (2017)
BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis.
American Journal of Respiratory and Critical Care Medicine, 177(1), 75-81 (2008)
Journal of cachexia, sarcopenia and muscle, 13(3), 1771-1784 (2022-03-24)
Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle fibrosis occurs in response to trauma, aging, or dystrophies and impairs muscle
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门