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质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D +12 to +18°, c = 1 in methanol: water (1:1)
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
[Ca+2].Fc3ccc(cc3)c4nc(nc(c4\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])C(C)C)N([S](=O)(=O)C)C.Fc1ccc(cc1)c2nc(nc(c2\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])C(C)C)N([S](=O)(=O)C)C
InChI
1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17-;/m11./s1
InChI key
LALFOYNTGMUKGG-BGRFNVSISA-L
一般描述
瑞舒伐他汀钙（ROS）具有1001.14的分子量。ROS是一种“他汀”类药物并且是3-羟基-3-甲基戊二酰的一种还原酶抑制剂。
应用
瑞舒伐他汀钙已被用于确定SIM、瑞舒伐他汀或PRA治疗对HeLa细胞中胆固醇和HMGCR水平的影响，并评估他汀类药物对葡萄糖体内平衡的体内作用。
生化/生理作用
瑞舒伐他汀钙是一种HMG-CoA还原酶抑制剂。
瑞舒伐他汀钙是羟甲基戊二酰辅酶A（HMG-CoA）还原酶的一种竞争性抑制剂，可催化HMG-CoA转化为甲羟戊酸，而这是胆固醇生物合成中的限速步骤。瑞舒伐他汀钙具有抗血脂效果，可用于降低血浆胆固醇水平，预防心血管疾病。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Cholesterol crystal formation is a unifying pathogenic mechanism in the development of diabetic retinopathy.
Hammer, et al.
Diabetologia (2023)
Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction.
Wang HJ, et al.
Autophagy, 11(11), 2089-2101 (2015)
Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review.
Angelo ML, et al.
Critical Reviews in Analytical Chemistry, 48(4), 317-329 (2018)
HPLC methods for recently approved pharmaceuticals (2005)
Joel P Wiener et al.
Cells, 12(17) (2023-09-08)
Adenosine triphosphate-binding cassette transporter subfamily A member 7 (ABCA7) is a major risk factor for Alzheimer's disease. Human neural cell lines were used to investigate the regulation of ABCA7 expression by cholesterol and pro-inflammatory cytokines. Cholesterol was depleted by methyl-β-cyclodextrin
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