SML1252
Treosulfan
≥98% (HPLC), Alkylating agent, powder
别名:
(2S,3S)-Butanetetraol 1,4-dimesylate, (2S,3S)-Threitol 1,4-bismethanesulfonate, L-Threitol 1,4-bis(methanesulfonate), NSC 39069, Threosulphan, Treosulphan
产品名称
Treosulfan, ≥98% (HPLC)
SMILES string
[S](=O)(=O)(OCC(O)C(O)CO[S](=O)(=O)C)C
InChI
1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3
InChI key
YCPOZVAOBBQLRI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -4.9 to -5.9°, c = 1 in acetone
color
white to beige
solubility
H2O: 5 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Treosulfan is bifunctional alkylating agent.
Alkylating agent, anti-neoplastic agent
Treosulfan is a biofunctional alkylating agent.
Treosulfan/l-threitol-1,4-bis-methanesulfonate; dihydroxybusulfan; NSC 39069. It is a prodrug of a bifunctional alkylating cytotoxic agent. Treosulfan can be activated non-enzymatically to two active epoxides. It is used to treat ovarian cancer.
signalword
Danger
hcodes
Hazard Classifications
Carc. 1A - Muta. 1B - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation
Casper J, et al.
Blood, 103(2), 725-731 (2004)
Pre-formulation investigations for establishing a protocol for treosulfan handling and activation
El-Serafi I, et al.
Pharmaceutical Development and Technology, 1-27 (2018)
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