质量水平
检测方案
≥96% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(C1=CC(NC(C=CCN(C)C)=O)=CC=C1)NC(C=C2C)=CC=C2NC3=NC=CC(C4=CC=CN=C4)=N3
InChI
1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)
InChI key
GJFCSAPFHAXMSF-UHFFFAOYSA-N
应用
JNK-IN-8 已用作抑制剂来研究 JNK 信号转导在醉茄素 A（WFA）诱导的骨髓增生异常综合征（MDS）-L 细胞凋亡中的重要性。
生化/生理作用
JNK-IN-8 和拉帕替尼通过诱导凋亡协同降低人三阴性乳腺癌（TNBC）细胞系中的细胞活力。JNK-IN-8 和拉帕替尼导致细胞毒性氧化应激的积累。
JNK-IN-8 是有效的、选择性和不可逆的 JNK1/2/3 抑制剂，可抑制 c-Jun 的磷酸化。JNK-IN-8 与保守的半胱氨酸残基形成共价键。
其他说明
JNK-IN-8 已由化学探针门户网站进行了专家审查和推荐。有关更多信息，请访问化学探针门户网站上的 JNK-IN-8 探针摘要。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A
Oben KZ, et al.
Oncotarget, 8(44), 77436?77452-77436?77452 (2017)
Eugene Y Kim et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201800425R-fj201800425R (2018-05-26)
Rheumatoid arthritis (RA) is characterized by hyperplastic pannus formation mediated by activated synovial fibroblasts (RASFs) that cause joint destruction. We have shown earlier that RASFs exhibit resistance to apoptosis, primarily as a result of enhanced expression of myeloid cell leukemia-1
A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.
Ebelt ND, et al.
Oncotarget, 8(62), 104894-104894 (2017)
Stefanie Dichtl et al.
Life science alliance, 5(4) (2022-01-15)
Anti-TNF therapies are a core anti-inflammatory approach for chronic diseases such as rheumatoid arthritis and Crohn's Disease. Previously, we and others found that TNF blocks the emergence and function of alternative-activated or M2 macrophages involved in wound healing and tissue-reparative
Yi Huang et al.
Antioxidants (Basel, Switzerland), 11(7) (2022-07-28)
Puerarin was shown to exert anti-oxidative and anti-ferroptosis effects in multiple diseases. The goal of this study was to explore the neuroprotective effect of puerarin on early brain injury (EBI) after subarachnoid hemorrhage (SAH) in rats. A total of 177
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