SML1241
Pyr6
≥98% (HPLC)
别名:
N- [4- [3,5-双（三氟甲基）-1H-吡唑-1-基]苯基] -3-氟-4-吡啶甲酰胺
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选择尺寸
关于此项目
经验公式（希尔记法）:
C17H9F7N4O
化学文摘社编号:
分子量:
418.27
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
Pyr6, ≥98% (HPLC)
SMILES string
O=C(C1=CC=NC=C1F)NC2=CC=C(N3C(C(F)(F)F)=CC(C(F)(F)F)=N3)C=C2
InChI
1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29)
InChI key
XZIQSOZOLJJMFN-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
Pyr6 是通过 STIM1/Orai1 介导的钙库操纵性钙内流（SOCE）从内质网释放钙的选择性抑制剂。
Pyr6 是通过 STIM1/Orai1 介导的钙库操纵性钙内流（SOCE）从内质网释放钙的选择性抑制剂。 Pyr6 可以在经毒胡萝卜素处理的缺钙 BRL-2H3 细胞中阻断 SOCE（IC50 = 0.49 μM），但在 TRPC3 转染的 HEK293 细胞中对卡巴胆碱诱导的 TRPC3 介导的钙内流的活性较弱（IC50 = 18.46 μM）。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Samuel Shin et al.
Cellular signalling, 67, 109484-109484 (2019-11-27)
Oxidative stress and reactive oxygen species (ROS) generation can be influenced by G-protein coupled receptor (GPCR)-mediated regulation of intracellular Ca2+ ([Ca2+]i) signaling. ROS production are much higher in proximal tubular (PT) cells; in addition, the lack of antioxidants enhances the
Prabir K Chakraborty et al.
Nature communications, 8, 14634-14634 (2017-05-23)
Cancer cells actively promote aerobic glycolysis to sustain their metabolic requirements through mechanisms not always clear. Here, we demonstrate that the gatekeeper of mitochondrial Ca
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