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About This Item
经验公式（希尔记法）:
C20H24N10O13P2 · xNa+
CAS号:
分子量:
674.41 (free acid basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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描述
contains 0.5μmol of powder (approx. 0.335mg)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
储存温度
−20°C
SMILES字符串
O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP4(O)=O)[C@H]3COP(O)(O[C@H]5[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O[C@@H]5CO4)=O.C
应用
cGAMP 钠盐已用于 cGAS-cGAMP 活性测定。
生化/生理作用
cGAMP 诱导细胞因子（干扰素-β，干扰素-γ）激活树突状细胞和 CD8 + T 细胞交叉致敏。通过这一操作，促进天然免疫反应。cGAMP 具有抗肿瘤活性，在癌症治疗中首选用于免疫治疗。
环腺苷酸 GMP (cGAMP) 是细菌第二信使。
环腺苷酸-GMP (cGAMP) 是几种天然存在的环二核苷酸之一，作为细菌第二信使调控原核生物中控制细菌存活、黏附、定植、生物膜形成和毒力因子产生的重要信号机制。霍乱时 c-AMP-GMP 通过下调趋化性促进肠道定植。在感染过程中，细菌 cGAMP 与宿主 STING（干扰素基因刺激物）结合，激活先天免疫应答，导致干扰素基因的表达。
制备说明
环 AMP-GMP 可溶于水和水性缓冲液（> 10 mM，尚未确定限度）。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response.
Li T, et al.
Scientific Reports, 6, 19049-19049 (2016)
Yong Shen et al.
Cell reports, 35(12), 109272-109272 (2021-06-24)
The type I interferon (IFN) pathway is a key component of innate immune response upon invasion of foreign pathogens. It is also under precise control to prevent excessive upregulation and undesired inflammation cascade. In the present study, we report that
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Andrea Annibal et al.
Analytical and bioanalytical chemistry, 413(26), 6457-6468 (2021-09-04)
Cyclic dinucleotides (CDNs) are key secondary messenger molecules produced by cyclic dinucleotide synthases that trigger various cellular signaling cascades from bacteria to vertebrates. In mammals, cyclic GMP-AMP synthase (cGAS) has been shown to bind to intracellular DNA and catalyze the
Dareen Mikheil et al.
Scientific reports, 14(1), 4440-4440 (2024-02-24)
3',5'-Cyclic adenosine monophosphate (cAMP), the first identified second messenger, is implicated in diverse cellular processes involving cellular metabolism, cell proliferation and differentiation, apoptosis, and gene expression. cAMP is synthesized by adenylyl cyclase (AC), which converts ATP to cAMP upon activation
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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