所有图片(1)
别名:
3′,5′-环二腺苷酸 钠盐, 环-di-AMP 钠盐, 环二-3′,5′-腺苷酸 钠盐, 环二腺苷酸 钠盐, 环二腺苷酸一磷酸 钠盐, 腺苷酰-(3′5′)-3′-腺苷酸，环核苷酸 钠盐
经验公式（希尔记法）:
C20H24N10O12P2 · xNa+
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描述
contains 1μmol of powder (approx. 0.7mg)
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
储存温度
−20°C
SMILES字符串
NC1=NC=NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP(OC[C@@H]4[C@@H](O5)[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O4)(O)=O)[C@H]3COP5(O)=O.C
InChI
1S/C20H24N10O12P2/c21-15-9-17(25-3-23-15)29(5-27-9)19-11(31)13-7(39-19)1-37-43(33,34)42-14-8(2-38-44(35,36)41-13)40-20(12(14)32)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-32H,1-2H2,(H,33,34)(H,35,36)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1
InChI key
PDXMFTWFFKBFIN-XPWFQUROSA-N
生化/生理作用
c-di-AMP 是细菌的第二信使。c-di-AMP 作为一种强效粘膜佐剂，可刺激体液和细胞应答。
在多种信号通路中起作用。在革兰氏阳性菌中，它影响细胞生长和存活，并调节毒力。c-di-AMP 是由二腺苷酸环化酶 (DAC) 形成的，DAC 是一种含有环化酶结构域的蛋白质。
制备说明
c-di-AMP 可溶于水（≥16 mM，尚未确定限值）。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Qichao Sun et al.
Enzyme and microbial technology, 143, 109700-109700 (2020-12-31)
Cyclic di-AMP is a bacterial nucleotide second messenger and evaluated as a potential vaccine adjuvant candidate. Here, we report a practical and economical enzymatic method for gram-scale preparation of c-di-AMP using an immobilized Vibrio cholerae dinucleotide cyclase DncV. The method
c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulence of Gram-Positive Bacteria
Fahmi T, et al.
Genes, 8(8), 197-197 (2017)
Andrea Annibal et al.
Analytical and bioanalytical chemistry, 413(26), 6457-6468 (2021-09-04)
Cyclic dinucleotides (CDNs) are key secondary messenger molecules produced by cyclic dinucleotide synthases that trigger various cellular signaling cascades from bacteria to vertebrates. In mammals, cyclic GMP-AMP synthase (cGAS) has been shown to bind to intracellular DNA and catalyze the
W Michael Babinchak et al.
Nature communications, 11(1), 5574-5574 (2020-11-06)
Liquid-liquid phase separation (LLPS) of proteins that leads to formation of membrane-less organelles is critical to many biochemical processes in the cell. However, dysregulated LLPS can also facilitate aberrant phase transitions and lead to protein aggregation and disease. Accordingly, there
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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