跳转至内容
Merck
CN
所有图片(2)

主要文件

查看所有文档

SML1229

Sigma-Aldrich

2′,3′-cGAMP 钠盐

≥98% (HPLC)

别名:

2′,5′-3′,5′-cGAMP, cGAMP(2′-5′), c[G(2′,5′)pA(3′,5′)p] 钠盐, 环化[G(2′,5′)pA(3′,5′)p]

登录查看公司和协议定价
所有图片(2)

About This Item

经验公式（希尔记法）:
C20H24N10O13P2 · xNa+
CAS号:
1441190-66-4
分子量:
674.41 (free acid basis)
UNSPSC代码:
51111800
PubChem化学物质编号:
329825733
NACRES:
NA.77

描述

contains 0.5μmol of powder (approx. 0.335mg)

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

储存温度

−20°C

SMILES字符串

O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](OP(OC[C@@H]4[C@@H](O5)[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O4)(O)=O)[C@H](O)[C@H]3COP5(O)=O

InChI

1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1

InChI key

XRILCFTWUCUKJR-INFSMZHSSA-N

应用

2′,3′-cGAMP钠盐被用来鉴定能够和人干扰素基因（STING）激活剂结合的小分子。它还被用来研究I型干扰素胞浆DNA应答。

生化/生理作用

2′,3′-cGAMP (环化[G(2′,5′)pA(3′,5′)p]) 是STING（干扰素基因激活剂）途径的天然兴奋剂，被发现是抗病毒先天免疫途径。2′3′-cGAMP是在哺乳动物细胞中，由胞质DNA传感器（CGAMP合成酶）通过结合STING，启动干扰素应答，激活先天免疫途径，而产生的二级信使。 2′3′-cGAMP和人STING亲和性比和细菌 3′3′-环化二核苷酸（CDNs）要高得多，1Kd是4.59 nMSTING，相比之下，结合细菌3′3′-CDNs是>1 μM。
2′,3′-cGAMP是hSTING的天然兴奋剂；二级信使环化二核苷酸。

制备说明

2′,3′-cGAMP可溶于水和水性缓冲液（>> 5 mM, 没有确定溶解极限）。

相关产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000197234
0000385454
0000383503
0000383503
0000197234

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Hua-Fang Bao et al.
The FEBS journal, 291(15), 3432-3453 (2024-04-28)
Inflammatory signals from immunological cells may cause damage to intestinal epithelial cells (IECs), resulting in intestinal inflammation and tissue impairment. Interferon-γ-inducible protein 16 (IFI16) was reported to be involved in the pathogenesis of Behçet's syndrome (BS). This study aimed to
Christos Dogrammatzis et al.
mBio, 15(4), e0037324-e0037324 (2024-03-12)
The STimulator of INterferon Genes (STING) constitutes a major DNA-sensing pathway that restricts HSV-1 infection in different models by activating type I interferon and pro-inflammatory responses. To counteract STING, HSV-1 has evolved numerous strategies including mechanisms to interfere with its
Qingyuan Zhu et al.
Antiviral research, 187, 105015-105015 (2021-01-15)
The newly emerged severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) coronavirus initiated a pneumonia outbreak (COVID-19) that rapidly spread worldwide and quickly became a public health emergency of international concern; However to date, except Remdesivir, there are no clinically approved specific or
Qingyuan Zhu et al.
Antiviral research, 183, 104933-104933 (2020-09-20)
Stimulator of interferon genes (STING), as a signaling hub in innate immunity, plays a central role for the effective initiation of host defense mechanisms against microbial infections. Upon binding of its ligand cyclic dinucleotides (CDNs) produced by the cyclic GMP-AMP
Jacques Greenberg et al.
JCI insight, 7(23) (2022-10-28)
Pancreatic neuroendocrine tumors (PNETs) are malignancies arising from the islets of Langerhans. Therapeutic options are limited for the over 50% of patients who present with metastatic disease. We aimed to identify mechanisms to remodel the PNET tumor microenvironment (TME) to
查看所有相关文献

商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门