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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
H2O: 5 mg/mL, clear (warmed)
储存温度
2-8°C
InChI
1S/C15H24N4O6S2.H2O/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25;/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25);1H2/t6-,7-,8+,9+,10-,11-;/m1./s1
InChI key
NTUBEBXBDGKBTJ-WGLOMNHJSA-N
生化/生理作用
Doripenem hydrate is used to treat complicated urinary infection including Pyelonephritis caused by E.coli. Doripenem hydrate is promoted in the United States as DORIBAX®. This drug is synthesized from p-nitrobenzyl-protected enolphosphate 2b and N-(p-nitrobenzyloxycarbonyl)-protected aminomethylpyrrolidine.
Doripenem is an ultra-broad spectrum carbopenem antibiotic. Doripenem is active against both gram-positive and gram-negative bacteria.
法律信息
DORIBAX is a registered trademark of Shionogi Inc.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Practical large-scale synthesis of doripenem: A novel 1β-methylcarbapenem antibiotic.
Organic Process Research & Development, 7(6), 846-850 (2003)
Improved Large-scale One-pot Synthesis of Pure Doripenem Hydrate (S-4661).
Organic Prep. and Proc. Int., 48(4), 342-349 (2016)
Frontiers in microbiology, 12, 598498-598498 (2021-02-16)
Pseudomonas aeruginosa utilizes the quorum sensing (QS) system to strategically coordinate virulence and biofilm formation. Targeting QS pathways may be a potential anti-infective approach to treat P. aeruginosa infections. In the present study, we define cephalosporins' anti-QS activity using Chromobacterium
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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