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Merck
CN
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主要文件

SML1210

Sigma-Aldrich

Almotriptan malate

≥98% (HPLC)

别名:

3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indole malate, PNU 180638

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About This Item

经验公式（希尔记法）:
C17H25N3O2S · C4H6O5
CAS号:
181183-52-8
分子量:
469.55
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 10 mg/mL, clear

储存温度

−20°C

SMILES字符串

[S](=O)(=O)(N3CCCC3)Cc1cc2c([nH]cc2CCN(C)C)cc1.OC(CC(=O)O)C(=O)O

InChI

1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)

InChI key

QHATUKWEVNMHRY-UHFFFAOYSA-N

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应用

Almotriptan at an oral dose of 12.5 mg, is recommended to be safe for treating migraine.
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.

生化/生理作用

Almotriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Almotriptan has low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower. Affinity for 5-HT(7) and 5-HT(1A) receptors was approximately 40 and 60 times lower than that for 5-HT(1B/1D) receptors, respectively.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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分析证书(COA)

Lot/Batch Number
0000406424
0000406424
0000129437
0000071133
0000071134

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Dose finding, placebo-controlled study of oral almotriptan in the acute treatment of migraine
Dahlof C, et al.
Neurology, 57(10), 1811-1817 (2001)
Long?term Efficacy and Safety of Oral Almotriptan: Interim Analysis of a 1?Year Open Study
Cabarrocas X, et al.
Headache, 41(1), 57-62 (2001)
Kremena Saracheva et al.
Acta pharmaceutica (Zagreb, Croatia), 70(2), 239-247 (2020-01-20)
The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses
Barbora Vyhlídalová et al.
International journal of molecular sciences, 21(8) (2020-04-23)
The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepatic and intestinal

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