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Merck
CN
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主要文件

安全信息

SML1187

Sigma-Aldrich

Vacquinol-1 dihydrochloride

≥98% (HPLC)

别名:

2-(4-Chlorophenyl)-α−2-piperidinyl-4-quinolinemethanol dihydrochloride, NSC13316

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About This Item

经验公式（希尔记法）:
C21H21ClN2O · 2HCl
CAS号:
5428-80-8
分子量:
425.78
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

Clc1ccc(cc1)c2nc3c(c(c2)C(O)C4NCCCC4)cccc3

InChI

1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2

InChI key

VKLJPGAHSLIQKH-UHFFFAOYSA-N

生化/生理作用

Vacquinol-1 (NSC13316) is a brain penetrant inducer of catastrophic vacuolization in glioblastoma cells (GCs). Vacquinol-1 displays high cytotoxicity to GCs; it induces cell death by membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture of GCs. Vacquinol-1 originally was developed as an antimalarial compound.
Vacquinol-1 dihydrochloride is potentially used as a therapeutic for Glioblastoma multiforme (GBM). This drug is highly stable in vivo, with a half-life in plasma of 52 hour. Vacquinol-1 has high oral bioavailability and good brain penetration.
Vacquinol-1 is a brain penetrant inducer of catastrophic vacuolization in glioblastoma cells.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000230068
0000230068
0000143812
0000143813
076M4609V

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