SML1169
Pitstop 2
≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor
别名:
N-[5-[（4-溴苯基）亚甲基]-4,5-二氢-4-氧代-2-噻唑基]-1-萘磺酰胺, Pitstop-2
产品名称
Pitstop 2, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
Pitstop 2 已被用作网格蛋白介导内吞作用的抑制剂。
Biochem/physiol Actions
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂。
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂，通过阻断配体进入网格蛋白末端结构域发挥作用。Pitstop 2 能选择性抑制网格蛋白介导的 HIV 进入，并阻止网格蛋白包覆的pit (CCP) 动力学。
Pitstop 2 还具有破坏核孔复合体 (NPC) 通透性屏障和降低输入蛋白 β结合，同时改变 NPC 超微结构。Pitstop 2 还参与抑制血小板活化、血小板聚集和分泌。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Clathrin-mediated integrin ?IIb?3 trafficking controls platelet spreading
Gao W, et al.
Platelets, 1-12 (2017)
Leucine-rich repeat-containing G protein?coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein
Zhang N, et al,
The Journal of Biological Chemistry, 292(40), 16527-16538 (2017)
Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier
Liashkovich I, et al.
Scientific Reports, 5, 9994-9994 (2015)
Muhammad Asam Riaz et al.
Journal of proteomics, 227, 103918-103918 (2020-07-28)
Bacterial insecticidal proteins, such as the Bin toxin from Lysinibacillus sphaericus, could be used more extensively to control insecticide resistant mosquitoes. This study was aimed at identification of mosquito cell proteins binding Bin toxin. Results showed that purified toxin was
Holger Haselmann et al.
Neuron, 100(1), 91-105 (2018-08-28)
AMPA receptors are essential for fast excitatory transmission in the CNS. Autoantibodies to AMPA receptors have been identified in humans with autoimmune encephalitis and severe defects of hippocampal function. Here, combining electrophysiology and high-resolution imaging with neuronal culture preparations and
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