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Merck
CN

SML1167

Sigma-Aldrich

4BP-TQS

≥98% (HPLC)

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别名:
4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
经验公式(希尔记法):
C18H17BrN2O2S
分子量:
405.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

SMILES字符串

BrC1=CC=C(C2C(CC=C3)C3C(C=C(S(N)(=O)=O)C=C4)=C4N2)C=C1

InChI

1S/C18H17BrN2O2S/c19-12-6-4-11(5-7-12)18-15-3-1-2-14(15)16-10-13(24(20,22)23)8-9-17(16)21-18/h1-2,4-10,14-15,18,21H,3H2,(H2,20,22,23)

InChI key

YNCXHXYZTLIZTO-UHFFFAOYSA-N

生化/生理作用

4BP-TQS is an atypical agonist of a7-nAChR that binds to the receptor in an intrasubunit cavity, and activates the channel via a mechanism that is distinct from conventional agonists. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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