质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
, white to yellow to light brown
溶解性
H2O: 2 mg/mL, clear (warmed)
储存温度
room temp
SMILES字符串
CC(C)N(CCC1)C[C@H]1CN(C(C)=N2)C(C3=C2C=CC(OC4=CC=C(F)C=C4)=C3)=O.Cl
InChI
1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1
InChI key
QQGRMONBDBMLSP-FERBBOLQSA-N
应用
YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.
生化/生理作用
YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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