SML1118
铁调素-25（人） 三氟乙酸盐
≥95% (HPLC)
别名:
H-Asp-Thr-His-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH 三氟乙酸盐, Hepc25（人）, LEAP-1（肝脏表达的抗菌肽）（人） 三氟乙酸盐, PLTR（推定的肝脏肿瘤消退者）（人）, dthfpicifcccgcchrskcgmckt 三氟乙酸盐
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About This Item
经验公式（希尔记法）:
C113H170N34O31S9 · xC2HF3O2
CAS号:
分子量:
2789.35 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.77
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Amino Acid Sequence
H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH trifluoroacetate salt
生化/生理作用
铁调素-25 是铁调素的主要同种型。铁调素-25 中的网织红细胞血红蛋白含量 (CHr) 有助于鉴别 DA 可将缺铁性贫血 (IDA) 与慢性病贫血 (ACD) 及 ACD/IDA 合并状态相鉴别。铁调素基因突变与严重青少年血色病的发生有关。
铁调素是铁稳态的主要调节因子。铁调素存在于肝脏中，但也广泛分布于脑中，可能在预防铁相关的神经退行性病变中发挥作用。铁调素具有抗炎和抗菌活性。
铁调素是铁稳态的主要调节因子，具有抗炎和抗菌活性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Association of prohepcidin and hepcidin-25 with erythropoietin response and ferritin in hemodialysis patients.
Kato A, et al.
American Journal of Nephrology, 28(1), 115-121 (2008)
Serum hepcidin?25 may replace the ferritin index in the Thomas plot in assessing iron status in anemic patients.
Thomas C, et al.
International Journal of Laboratory Hematology, 33(2), 187-193 (2011)
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis.
Roetto A, et al.
Nature Genetics, 33(1), 21-21 (2003)
Jiemin Shen et al.
eLife, 12 (2023-01-18)
Ferroportin (Fpn) is a transporter that releases ferrous ion (Fe2+) from cells and is important for homeostasis of iron in circulation. Export of one Fe2+ by Fpn is coupled to import of two H+ to maintain charge balance. Here, we
Jin-Seon Yook et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(40) (2021-10-02)
Iron is an essential biometal, but is toxic if it exists in excess. Therefore, iron content is tightly regulated at cellular and systemic levels to meet metabolic demands but to avoid toxicity. We have recently reported that adaptive thermogenesis, a
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