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质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to light brown
溶解性
DMSO: 0.5 mg/mL, clear (warmed)
储存温度
−20°C
SMILES字符串
O=C1C2=C(CCS2)N=C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)N1C5=C(OC)C=CC=C5
InChI
1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
InChI key
RHUJMHOIQBDFQR-UHFFFAOYSA-N
生化/生理作用
IWP-4 是 Wnt 通路调节蛋白 Porupine（Porcn）的有效抑制剂。
IWP-4 是 Wnt 通路调节蛋白 Porupine（Porcn）的有效抑制剂。 IWP-4 阻断棕榈酸酯化以及随后的 Wnt 分泌和活性。 IWP-4 诱导人多能干细胞分化为心肌细胞。
IWP-4 阻断 Wnt 家族成员 5a。它阻断 Wnt 蛋白分泌，并阻断经典和非经典信号通路。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Alla Narytnyk et al.
Stem cell reviews, 10(2), 316-326 (2014-01-09)
Here we provide a protocol for the directed differentiation of hEPI-NCSC into midbrain dopaminergic neurons, which degenerate in Parkinson's disease. hEPI-NCSC are neural crest-derived multipotent stem cells that persist into adulthood in the bulge of hair follicles. The experimental design
Qinghua Wang et al.
Communications biology, 5(1), 1018-1018 (2022-09-28)
The formation of wound epithelium initiates regeneration of amputated tail in Gekko japonicus. Energy metabolism is indispensable for the growth of living creatures and typically influenced by temperature. In this study, we reveal that low temperature lowers energy metabolism level
Microbioreactor Array Screening of Wnt Modulators and Microenvironmental Factors in Osteogenic Differentiation of Mesenchymal Progenitor Cells
Frith JE, et al.
PLoS ONE, 8(12), e82931-e82931 (2013)
Oliver Schneider et al.
Materials today. Bio, 15, 100280-100280 (2022-05-24)
Over the last decade, Organ-on-Chip (OoC) emerged as a promising technology for advanced in vitro models, recapitulating key physiological cues. OoC approaches tailored for cardiac tissue engineering resulted in a variety of platforms, some of which integrate stimulation or probing
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