SML1109
KU-55933
≥98% (HPLC), Ataxia telangiectasia (A-T) mutated (ATM) kinase inhibitor, powder
别名:
2-(4-吗啉基)-6-(1-噻蒽基)-4H-吡喃-4-酮, 2-(吗啉-4-基)-6-(噻蒽-1-基)-4H-吡喃-4-酮
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选择尺寸
关于此项目
经验公式（希尔记法）:
C21H17NO3S2
化学文摘社编号:
分子量:
395.49
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
KU-55933, ≥98% (HPLC)
SMILES string
O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5
InChI
1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChI key
XRKYMMUGXMWDAO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
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Application
KU-55933已被用作共济失调-毛细血管扩张症突变（ATM）抑制剂。
Biochem/physiol Actions
KU-55933是一种非常有效的共济失调毛细血管扩张症（A-T）突变（ATM）激酶特异性抑制剂。
KU-55933是一种非常有效的共济失调毛细血管扩张症（A-T）突变（ATM）激酶特异性抑制剂（IC50 = 13 nM）。KU-22933处理可增强癌细胞对电离辐射和细胞毒性药物的敏感性。化合物KU-22933能够阻断ATM介导的p53、gH2AX、NBS1和SMC1的磷酸化。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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