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Merck
CN

SML1103

恩替卡韦

≥98% (HPLC), Nucleic acid synthesis inhibitor, powder

别名:

2-氨基-1,9-二氢-9-[（1S，3R，4S）-4-羟基-3-（羟甲基）-2-亚甲基环戊基] -6H-嘌呤-6-酮, 2-氨基-9-[（（1S，3R，4S）-4-羟基-3-羟甲基-2-亚甲基-环戊基] -3,9-二氢嘌呤-6-酮, BMS 200475, SQ 34,676

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关于此项目

经验公式（希尔记法）:
C12H15N5O3
化学文摘社编号:
142217-69-4
分子量:
277.28
UNSPSC Code:
51111800
PubChem Substance ID:
329825478
NACRES:
NA.77
MDL number:
MFCD11046562

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产品名称

恩替卡韦, ≥98% (HPLC)

SMILES string

O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1

InChI

1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1

InChI key

QDGZDCVAUDNJFG-FXQIFTODSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +25 to +40°, c = 0.2 in H2O

storage condition

desiccated

color

white to beige

solubility

H2O: 0.5 mg/mL, clear (warmed)

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

恩替卡韦是一种抗病毒鸟嘌呤类似物，可在病毒复制过程中抑制逆转录、DNA复制和转录。 恩替卡韦可用于治疗乙型肝炎。
恩替卡韦是一种抗病毒鸟嘌呤类似物，可抑制逆转录、DNA复制和转录。
恩替卡韦被用作治疗慢性乙型肝炎病毒（CHB）携带的拉米夫定难治性患者的有效药物（每日1 mg剂量）。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H351

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000341185
0000341185
0000397849
0000283684
0000245721

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Michiyo Hayakawa et al.
Scientific reports, 10(1), 47-47 (2020-01-09)
Nucleos(t)ide analog (NA) therapy has proven effective in treating chronic hepatitis B. However, NAs frequently result in viral relapse after the cessation of therapy. This is because NAs cannot fully eliminate the viral episomal covalently closed circular DNA (cccDNA) in
Masashi Iwamoto et al.
Scientific reports, 7(1), 10620-10620 (2017-09-08)
Viruses exploit host factors and environment for their efficient replication. The virus-host interaction mechanisms for achieving an optimal hepatitis B virus (HBV) replication have been largely unknown. Here, a single cell cloning revealed that HepAD38 cells, a widely-used HBV-inducible cell
Amir Shlomai et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(33), 12193-12198 (2014-08-06)
Hepatitis B virus (HBV) chronically infects 400 million people worldwide and is a leading driver of end-stage liver disease and liver cancer. Research into the biology and treatment of HBV requires an in vitro cell-culture system that supports the infection
Philip Rosenthal et al.
Hepatology (Baltimore, Md.), 69(6), 2326-2337 (2018-10-16)
The optimal management strategy for children with immune-tolerant chronic hepatitis B virus (HBV) infection remains unknown. The purpose of this clinical trial was to determine the safety and efficacy of therapy with entecavir and peginterferon in a group of children
Entecavir therapy for lamivudine?refractory chronic hepatitis B: improved virologic, biochemical, and serology outcomes through 96 weeks.
Sherman M, et al.
Hepatology, 48(1), 99-108 (2008)
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